Xavier Untereiner1, Audrey Cagniet2, Riccardo Memeo1,3,4, Zineb Cherkaoui1, Tullio Piardi2, François Severac5, Didier Mutter1,3,4, Reza Kianmanesh2, Taiga Wakabayashi1,3, Daniele Sommacale2, Patrick Pessaux6,7,8,9. 1. Digestive and Endocrine Surgery Unit, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France. 2. General, Digestive, and Endocrine Surgery Unit, Hôpital Robert Debré, Centre Hospitalier Universitaire de Reims, Université de Reims Champagne-Ardenne, Reims, France. 3. Research Institute Against Digestive Cancer (IRCAD), Strasbourg, France. 4. Institute of Image-Guided Surgery (IHU Mix-Surg), Strasbourg, France. 5. Laboratory of Biostatistics and Medical Computer Science, School of Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. 6. Digestive and Endocrine Surgery Unit, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France. patrick.pessaux@chru-strasbourg.fr. 7. Research Institute Against Digestive Cancer (IRCAD), Strasbourg, France. patrick.pessaux@chru-strasbourg.fr. 8. Institute of Image-Guided Surgery (IHU Mix-Surg), Strasbourg, France. patrick.pessaux@chru-strasbourg.fr. 9. Hepatobiliary and Pancreatic Surgical Unit, Nouvel Hôpital Civil (NHC), 1, place de l'hôpital, 67091, Strasbourg, France. patrick.pessaux@chru-strasbourg.fr.
Abstract
OBJECTIVES: The aim of this study was to compare the results between laparoscopic hepatectomy and open hepatectomy in two French university hospitals, for the management of hepatocellular carcinoma (HCC) using a propensity score matching. MATERIALS AND METHODS: A patient in the laparoscopic surgery group (LA) was randomly matched with another patient in the open approach group (OA) using a 1:1 allocated ratio with the nearest estimated propensity score. Matching criteria included age, presence of comorbidities, American Society of Anesthesiologists score, and resection type (major or minor). Patients of the LA group without matches were excluded. Intraoperative and postoperative data were compared in both groups. Survival was compared in both groups using the following matching criteria: number and size of lesions, alpha-fetoprotein rate, and cell differentiation. RESULTS: From January 2012 to January 2017, a total of 447 hepatectomies were consecutively performed, 99 hepatectomies of which were performed for the management of hepatocellular carcinomas. Forty-nine resections were performed among the open approach (OA) group (49%), and 50 resections were performed among the laparoscopic surgery (LA) group (51%). Mortality rate was 2% in the LA group and 4.1% in the OA group. After propensity score matching, there was a statistical difference favorable to the LA group regarding medical complications (54.55% versus 27.27%, p = 0.04), and operating times were shorter (p = 0.03). Resection rate R0 was similar between both groups: 90.91% (n = 30) in the LA group and 84.85% (n =) in the OA group. There was no difference regarding overall survival (p = 0.98) and recurrence-free survival (p = 0.42). CONCLUSIONS: Laparoscopic liver resection for the management of HCC seems to provide the same short-term and long-term results as compared to the open approach. Laparoscopic liver resections could be considered as an alternative and become the gold standard in well-selected patients.
OBJECTIVES: The aim of this study was to compare the results between laparoscopic hepatectomy and open hepatectomy in two French university hospitals, for the management of hepatocellular carcinoma (HCC) using a propensity score matching. MATERIALS AND METHODS: A patient in the laparoscopic surgery group (LA) was randomly matched with another patient in the open approach group (OA) using a 1:1 allocated ratio with the nearest estimated propensity score. Matching criteria included age, presence of comorbidities, American Society of Anesthesiologists score, and resection type (major or minor). Patients of the LA group without matches were excluded. Intraoperative and postoperative data were compared in both groups. Survival was compared in both groups using the following matching criteria: number and size of lesions, alpha-fetoprotein rate, and cell differentiation. RESULTS: From January 2012 to January 2017, a total of 447 hepatectomies were consecutively performed, 99 hepatectomies of which were performed for the management of hepatocellular carcinomas. Forty-nine resections were performed among the open approach (OA) group (49%), and 50 resections were performed among the laparoscopic surgery (LA) group (51%). Mortality rate was 2% in the LA group and 4.1% in the OA group. After propensity score matching, there was a statistical difference favorable to the LA group regarding medical complications (54.55% versus 27.27%, p = 0.04), and operating times were shorter (p = 0.03). Resection rate R0 was similar between both groups: 90.91% (n = 30) in the LA group and 84.85% (n =) in the OA group. There was no difference regarding overall survival (p = 0.98) and recurrence-free survival (p = 0.42). CONCLUSIONS: Laparoscopic liver resection for the management of HCC seems to provide the same short-term and long-term results as compared to the open approach. Laparoscopic liver resections could be considered as an alternative and become the gold standard in well-selected patients.
Authors: Daniel Cherqui; Alexis Laurent; Claude Tayar; Stephen Chang; Jeanne Tran Van Nhieu; Jérôme Loriau; Mehdi Karoui; Christophe Duvoux; Daniel Dhumeaux; Pierre-Louis Fagniez Journal: Ann Surg Date: 2006-04 Impact factor: 12.969