| Literature DB >> 30340038 |
Joshua B Sheetz1, Mark A Lemmon2.
Abstract
Understanding protein kinase family members that lack key catalytic residues-or pseudokinases-is a major challenge in cell signaling. In this issue of Cell, Sreelatha et al. (2018) describe how one pseudokinase transfers adenosine monophosphate (AMP) rather than phosphate to protein substrates, revealing unexpected catalytic diversity for the kinase fold.Entities:
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Year: 2018 PMID： 30340038 PMCID： PMC6421561 DOI： 10.1016/j.cell.2018.10.011
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582