Literature DB >> 30339254

An Assessment of Potential Unintended Consequences Following a National Antimicrobial Stewardship Program in England: An Interrupted Time Series Analysis.

Violeta Balinskaite1, Sabine Bou-Antoun2,3, Alan P Johnson3,4, Alison Holmes2, Paul Aylin1,2,3.   

Abstract

BACKGROUND: The "Quality Premium" (QP) introduced in England in 2015 aimed to financially reward local healthcare commissioners for targeted reductions in primary care antibiotic prescribing. We aimed to evaluate possible unintended clinical outcomes related to this QP.
METHODS: Using Clinical Practice Research Datalink and Hospital Episode Statistics datasets, we examined general practitioner (GP) consultations (visits) and emergency hospital admissions related to a series of predefined conditions of unintended consequences of reduced prescribing. Monthly age- and sex-standardized rates were calculated using a direct method of standardization. We used segmented regression analysis of interrupted time series to evaluate the impact of the QP on seasonally adjusted outcome rates.
RESULTS: We identified 27334 GP consultations and >5 million emergency hospital admissions with predefined conditions. There was no evidence that the QP was associated with changes in GP consultation and hospital admission rates for the selected conditions combined. However, when each condition was considered separately, a significant increase in hospital admission rates was noted for quinsy, and significant decreases were seen for hospital-acquired pneumonia, scarlet fever, pyelonephritis, and complicated urinary tract conditions. A significant decrease in GP consultation rates was estimated for empyema and scarlet fever. No significant changes were observed for other conditions.
CONCLUSIONS: Findings from this study show that overall there was no significant association between the intervention and unintended clinical consequences, with the exception of a few specific conditions, most of which could be explained through other parallel policy changes or should be interpreted with caution due to small numbers.
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  antibiotic prescribing; antimicrobial stewardship programs; interrupted time series; primary and secondary care; unintended consequences

Mesh:

Substances:

Year:  2019        PMID: 30339254     DOI: 10.1093/cid/ciy904

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  7 in total

1.  Peritonsillar Abscess and Antibiotic Prescribing for Respiratory Infection in Primary Care: A Population-Based Cohort Study and Decision-Analytic Model.

Authors:  Joanne R Winter; Judith Charlton; Mark Ashworth; Catey Bunce; Martin C Gulliford
Journal:  Ann Fam Med       Date:  2020-09       Impact factor: 5.166

2.  Probability of sepsis after infection consultations in primary care in the United Kingdom in 2002-2017: Population-based cohort study and decision analytic model.

Authors:  Martin C Gulliford; Judith Charlton; Joanne R Winter; Xiaohui Sun; Emma Rezel-Potts; Catey Bunce; Robin Fox; Paul Little; Alastair D Hay; Michael V Moore; Mark Ashworth
Journal:  PLoS Med       Date:  2020-07-23       Impact factor: 11.069

3.  Antimicrobial resistance associations with national primary care antibiotic stewardship policy: Primary care-based, multilevel analytic study.

Authors:  Ashley Hammond; Bobby Stuijfzand; Matthew B Avison; Alastair D Hay
Journal:  PLoS One       Date:  2020-05-14       Impact factor: 3.240

4.  Investigating the impact of COVID-19 on primary care antibiotic prescribing in North West London across two epidemic waves.

Authors:  Nina Zhu; Paul Aylin; Timothy Rawson; Mark Gilchrist; Azeem Majeed; Alison Holmes
Journal:  Clin Microbiol Infect       Date:  2021-02-16       Impact factor: 8.067

5.  The impact of COVID-19 on community antibiotic use in Canada: an ecological study.

Authors:  Braden D Knight; Jayson Shurgold; Glenys Smith; Derek R MacFadden; Kevin L Schwartz; Nick Daneman; Denise Gravel Tropper; James Brooks
Journal:  Clin Microbiol Infect       Date:  2021-10-30       Impact factor: 8.067

6.  Associations between declining antibiotic use in primary care in Scotland and hospitalization with infection and patient satisfaction: longitudinal population study.

Authors:  Isobel Guthrie; William Malcolm; Rita Nogueira; Jacqueline Sneddon; R Andrew Seaton; Charis A Marwick
Journal:  J Antimicrob Chemother       Date:  2022-08-25       Impact factor: 5.758

7.  Proxy indicators to estimate appropriateness of antibiotic prescriptions by general practitioners: a proof-of-concept cross-sectional study based on reimbursement data, north-eastern France 2017.

Authors:  Nathalie Thilly; Ouarda Pereira; Jeroen Schouten; Marlies Ejl Hulscher; Céline Pulcini
Journal:  Euro Surveill       Date:  2020-07
  7 in total

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