Literature DB >> 30339190

The Impact of a National Antimicrobial Stewardship Program on Antibiotic Prescribing in Primary Care: An Interrupted Time Series Analysis.

Violeta Balinskaite1, Alan P Johnson2,3, Alison Holmes3, Paul Aylin1,3.   

Abstract

BACKGROUND: The Quality Premium was introduced in 2015 to financially reward local commissioners of healthcare in England for targeted reductions in antibiotic prescribing in primary care.
METHODS: We used a national antibiotic prescribing dataset from April 2013 until February 2017 to examine the number of antibiotic items prescribed, the total number of antibiotic items prescribed per STAR-PU (specific therapeutic group age/sex-related prescribing units), the number of broad-spectrum antibiotic items prescribed, and broad-spectrum antibiotic items prescribed, expressed as a percentage of the total number of antibiotic items. To evaluate the impact of the Quality Premium on antibiotic prescribing, we used a segmented regression analysis of interrupted time series data.
RESULTS: During the study period, over 140 million antibiotic items were prescribed in primary care. Following the introduction of the Quality Premium, antibiotic items prescribed decreased by 8.2%, representing 5933563 fewer antibiotic items prescribed during the 23 post-intervention months, as compared with the expected numbers based on the trend in the pre-intervention period. After adjusting for the age and sex distribution in the population, the segmented regression model also showed a significant relative decrease in antibiotic items prescribed per STAR-PU. A similar effect was found for broad-spectrum antibiotics (comprising 10.1% of total antibiotic prescribing), with an 18.9% reduction in prescribing.
CONCLUSIONS: This study shows that the introduction of financial incentives for local commissioners of healthcare to improve the quality of prescribing was associated with a significant reduction in both total and broad-spectrum antibiotic prescribing in primary care in England.
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords:  antibiotic prescribing; antimicrobial stewardship programs; interrupted time series

Mesh:

Substances:

Year:  2019        PMID: 30339190     DOI: 10.1093/cid/ciy902

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN: 1058-4838            Impact factor:   9.079


  13 in total

1.  The use of postal audit and feedback among Irish General Practitioners for the self - management of antimicrobial prescribing: a qualitative study.

Authors:  Kevin F Roche; Eimear C Morrissey; Julie Cunningham; Gerard J Molloy
Journal:  BMC Prim Care       Date:  2022-04-18

2.  The effect of primary care availability on antibiotic consumption in Hungary: a population based panel study using unfilled general practices.

Authors:  Aniko Biro; Peter Elek
Journal:  BMJ Open       Date:  2019-09-13       Impact factor: 2.692

3.  Investigating the mechanism of impact and differential effect of the Quality Premium scheme on antibiotic prescribing in England: a longitudinal study.

Authors:  Philip Emeka Anyanwu; Koen Pouwels; Anne Walker; Michael Moore; Azeem Majeed; Benedict W J Hayhoe; Sarah Tonkin-Crine; Aleksandra Borek; Susan Hopkins; Monsey Mcleod; Céire Costelloe
Journal:  BJGP Open       Date:  2020-08-25

4.  Trends in Antibiotic Prescribing in Out-of-Hours Primary Care in England from January 2016 to June 2020 to Understand Behaviours during the First Wave of COVID-19.

Authors:  Nina J Zhu; Monsey McLeod; Cliodna A M McNulty; Donna M Lecky; Alison H Holmes; Raheelah Ahmad
Journal:  Antibiotics (Basel)       Date:  2021-01-01

5.  Investigating the impact of COVID-19 on primary care antibiotic prescribing in North West London across two epidemic waves.

Authors:  Nina Zhu; Paul Aylin; Timothy Rawson; Mark Gilchrist; Azeem Majeed; Alison Holmes
Journal:  Clin Microbiol Infect       Date:  2021-02-16       Impact factor: 8.067

6.  Comparing public attitudes, knowledge, beliefs and behaviours towards antibiotics and antimicrobial resistance in Australia, United Kingdom, and Sweden (2010-2021): A systematic review, meta-analysis, and comparative policy analysis.

Authors:  Olivia Hawkins; Anna Mae Scott; Amy Montgomery; Bevan Nicholas; Judy Mullan; Antoine van Oijen; Chris Degeling
Journal:  PLoS One       Date:  2022-01-14       Impact factor: 3.240

7.  A pragmatic randomized trial of a primary care antimicrobial stewardship intervention in Ontario, Canada.

Authors:  Warren McIsaac; Sahana Kukan; Ella Huszti; Leah Szadkowski; Braden O'Neill; Sophia Virani; Noah Ivers; Rosemarie Lall; Navsheer Toor; Mruna Shah; Ruby Alvi; Aashka Bhatt; Yoshiko Nakamachi; Andrew M Morris
Journal:  BMC Fam Pract       Date:  2021-09-15       Impact factor: 2.497

8.  Serious bacterial infections and antibiotic prescribing in primary care: cohort study using electronic health records in the UK.

Authors:  Martin C Gulliford; Xiaohui Sun; Judith Charlton; Joanne R Winter; Catey Bunce; Olga Boiko; Robin Fox; Paul Little; Michael Moore; Alastair D Hay; Mark Ashworth
Journal:  BMJ Open       Date:  2020-02-28       Impact factor: 2.692

9.  Conceptualising the Integration of Strategies by Clinical Commissioning Groups in England towards the Antibiotic Prescribing Targets for the Quality Premium Financial Incentive Scheme: A Short Report.

Authors:  Philip Emeka Anyanwu; Aleksandra J Borek; Sarah Tonkin-Crine; Elizabeth Beech; Céire Costelloe
Journal:  Antibiotics (Basel)       Date:  2020-01-23

10.  Proxy indicators to estimate appropriateness of antibiotic prescriptions by general practitioners: a proof-of-concept cross-sectional study based on reimbursement data, north-eastern France 2017.

Authors:  Nathalie Thilly; Ouarda Pereira; Jeroen Schouten; Marlies Ejl Hulscher; Céline Pulcini
Journal:  Euro Surveill       Date:  2020-07
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