Literature DB >> 3033823

Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome.

R Longnecker, B Roizman.   

Abstract

The herpes simplex virus 1 genome consists of one long and one short stretch of unique sequences flanked by inverted repeat sequences. The nucleotide sequence and RNA map predict 12 open reading frames designated as US1 through US12 within the short stretch of unique sequences. This paper reports the construction of virus mutants from which US2, US3, or US4 had been deleted that are capable of growth in cell culture. One of the three deleted genes, US4, specifies the viral envelope glycoprotein G. Mutants with deletions in US1, US8, US9, US10, US11, and US12 have been previously reported. The nine genes deleted from this region form two clusters, US1 through US4 and US8 through US12, and encode at least two and possibly more structural proteins. The presence of so many genes dispensable for growth in cell culture suggests several hypotheses regarding their function and evolution.

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Year:  1987        PMID： 3033823     DOI： 10.1126/science.3033823

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  86 in total

1.  Herpes simplex virus glycoproteins gD and gE/gI serve essential but redundant functions during acquisition of the virion envelope in the cytoplasm.

Authors:  Aaron Farnsworth; Kimberly Goldsmith; David C Johnson
Journal:  J Virol       Date:  2003-08       Impact factor: 5.103

2.  The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22.

Authors:  F C Purves; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-15       Impact factor: 11.205

3.  UL34, the target of the herpes simplex virus U(S)3 protein kinase, is a membrane protein which in its unphosphorylated state associates with novel phosphoproteins.

Authors:  F C Purves; D Spector; B Roizman
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

4.  Bovine herpesvirus type 2 is closely related to the primate alphaherpesviruses.

Authors:  B Ehlers; M Goltz; M P Ejercito; G K Dasika; G J Letchworth
Journal:  Virus Genes       Date:  1999       Impact factor: 2.332

5.  Nucleotide sequence of the pseudorabies virus immediate early gene, encoding a strong transactivator protein.

Authors:  C Vlcek; V Paces; M Schwyzer
Journal:  Virus Genes       Date:  1989-08       Impact factor: 2.332

6.  Genome of bovine herpesvirus 5.

Authors:  G Delhon; M P Moraes; Z Lu; C L Afonso; E F Flores; R Weiblen; G F Kutish; D L Rock
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

7.  Characterization of Marek's disease virus insertion and deletion mutants that lack US1 (ICP22 homolog), US10, and/or US2 and neighboring short-component open reading frames.

Authors:  M S Parcells; A S Anderson; J L Cantello; R W Morgan
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.

Authors:  G L Demmin; A C Clase; J A Randall; L W Enquist; B W Banfield
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

9.  Nucleotide sequence analysis of an infectious laryngotracheitis virus gene corresponding to the US3 of HSV-1 and a unique gene encoding a 67 kDa protein.

Authors:  K Kongsuwan; C T Prideaux; M A Johnson; M Sheppard; S Rhodes
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574

10.  HSV type 1 genome variants from persistently productive infections in Raji and BJAB cell lines.

Authors:  S M Klauck; W Hampl; A K Kleinschmidt
Journal:  Arch Virol       Date:  1995       Impact factor: 2.574
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