Wavelet-based method for removing global physiological noise in functional near-infrared spectroscopy.

Functional near-infrared spectroscopy (fNIRS) is a fast-developing non-invasive functional brain imaging technology widely used in cognitive neuroscience, clinical research and neural engineering. However, it is a challenge to effectively remove the global physiological noise in the fNIRS signal. The global physiological noise in fNIRS arises from multiple physiological origins in both superficial tissues and the brain. It has complex temporal, spatial and frequency characteristics, casting significant influence on the results. In the present study, we developed a novel wavelet-based method for fNIRS global physiological noise removal. The method is data-driven and does not rely on any additional hardware or subjective noise component selection procedure. It consists of two steps. Firstly, we use wavelet transform coherence to automatically detect the time-frequency points contaminated by the global physiological noise. Secondly, we decompose the fNIRS signal by using the wavelet transform, and then suppress the wavelet energy of the contaminated time-frequency points. Finally, we transform the signal back to a time series. We validated the method by using simulation and real data at both task- and resting-state. The results showed that our method can effectively remove the global physiological noise from the fNIRS signal and improve the spatial specificity of the task activation and the resting-state functional connectivity pattern.