To the Editor,El Ouazzani et al. [1] nicely described the clinical picture and imaging and anatomopathological findings as well as treatment protocol of huge right ventricular mass secondary to a testicular germ cell tumor (GCT) in a Moroccan patient. I presume that the rare occurrence of intraventricular metastasis of that testicular GCT should alert the authors to consider compromised immune status in the studied patient. Among immunocompromised states, infection with human immunodeficiency virus (HIV) is the leading concern. My presumption is based on the following point. It is obvious that individuals infected with HIV are more vulnerable to various types of tumors compared with those with healthy immune system. Different factors have been suggested to explain the increased vulnerability of HIV-positive individuals to have tumors, including co-infection with oncogenic viruses, immunosuppression, and prolongation of life owing to the use of antiretroviral treatment [2]. Among tumors, testicular tumors have been reported in HIV-positive patients [3], [4]. To my knowledge, HIV infection is an important health problem in Morocco. Although no recent data are present on the magnitude of HIV infection in Morocco, the available data pointed to the substantial magnitude with 0.03 (0.02–0.04) HIV incidence per 1000 population (all ages) [5]. I presume that the authors ought to consider underling HIV infection in the studied patient. Hence, determination of HIV status in the studied patient through the diagnostic battery of viral overload and blood CD4 lymphocyte count estimations was envisaged. If that diagnostic battery was performed and it disclosed HIV infection, the case in question could be truly regarded a novel case report. This is because an unusual intracardiac metastasis of gonadal GCT in HIV-positive patients has not been reported in the world literature so far.