G Conte1, L Caschera2, S Calloni2, S Barozzi3, F Di Berardino3, D Zanetti3, C Scuffi4, E Scola5, C Sina5, F Triulzi5,6. 1. From the Neuroradiology Unit (G.C., E.S., C. Sina, F.T.), Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy giorgioconte.unimed@gmail.com. 2. Postgraduation School of Radiodiagnostics (L.C., S.C.). 3. Audiology Unit (S.B., F.D.B., D.Z.), Department of Clinical Sciences and Community, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy. 4. Departments of Medicine and Surgery (C. Scuffi). 5. From the Neuroradiology Unit (G.C., E.S., C. Sina, F.T.), Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy. 6. Pathophysiology and Transplantation (F.T.), Università degli Studi di Milano, Milan, Italy.
Abstract
BACKGROUND AND PURPOSE: No reliable MR imaging marker for the diagnosis of Menière disease has been reported. Our aim was to investigate whether the obliteration of the inferior portion of the vestibule and the contact with the stapes footplate by the vestibular endolymphatic space are reliable MR imaging markers in the diagnosis of Menière disease. MATERIALS AND METHODS: We retrospectively enrolled 49 patients, 24 affected by unilateral sudden hearing loss and 25 affected by definite Menière disease, who had undergone a 4-hour delayed 3D-FLAIR sequence. Two readers analyzed the MR images investigating whether the vestibular endolymphatic space bulged in the third inferior portion of the vestibule contacting the stapes footplate. This sign was defined as the vestibular endolymphatic space contacting the oval window. RESULTS: We analyzed 98 ears: 27 affected by Menière disease, 24 affected by sudden sensorineural hearing loss, and 47 that were healthy. The vestibular endolymphatic space contacting the oval window showed an almost perfect interobserver agreement (Cohen κ = 0.87; 95% CI, 0.69-1). The vestibular endolymphatic space contacting oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 88%, and negative predictive value = 93% in differentiating Menière disease ears from other ears. The vestibular endolymphatic space contacting the oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 96%, negative predictive value = 82% in differentiating Menière disease ears from sudden sensorineural hearing loss ears. CONCLUSIONS: The vestibular endolymphatic space contacting the oval window has high specificity and positive predictive value in differentiating Menière disease ears from other ears, thus resulting in a valid tool for ruling in Menière disease in patients with mimicking symptoms.
BACKGROUND AND PURPOSE: No reliable MR imaging marker for the diagnosis of Menière disease has been reported. Our aim was to investigate whether the obliteration of the inferior portion of the vestibule and the contact with the stapes footplate by the vestibular endolymphatic space are reliable MR imaging markers in the diagnosis of Menière disease. MATERIALS AND METHODS: We retrospectively enrolled 49 patients, 24 affected by unilateral sudden hearing loss and 25 affected by definite Menière disease, who had undergone a 4-hour delayed 3D-FLAIR sequence. Two readers analyzed the MR images investigating whether the vestibular endolymphatic space bulged in the third inferior portion of the vestibule contacting the stapes footplate. This sign was defined as the vestibular endolymphatic space contacting the oval window. RESULTS: We analyzed 98 ears: 27 affected by Menière disease, 24 affected by sudden sensorineural hearing loss, and 47 that were healthy. The vestibular endolymphatic space contacting the oval window showed an almost perfect interobserver agreement (Cohen κ = 0.87; 95% CI, 0.69-1). The vestibular endolymphatic space contacting oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 88%, and negative predictive value = 93% in differentiating Menière disease ears from other ears. The vestibular endolymphatic space contacting the oval window showed the following: sensitivity = 81%, specificity = 96%, positive predictive value = 96%, negative predictive value = 82% in differentiating Menière disease ears from sudden sensorineural hearing loss ears. CONCLUSIONS: The vestibular endolymphatic space contacting the oval window has high specificity and positive predictive value in differentiating Menière disease ears from other ears, thus resulting in a valid tool for ruling in Menière disease in patients with mimicking symptoms.
Authors: Robert J Stachler; Sujana S Chandrasekhar; Sanford M Archer; Richard M Rosenfeld; Seth R Schwartz; David M Barrs; Steven R Brown; Terry D Fife; Peg Ford; Theodore G Ganiats; Deena B Hollingsworth; Christopher A Lewandowski; Joseph J Montano; James E Saunders; Debara L Tucci; Michael Valente; Barbara E Warren; Kathleen L Yaremchuk; Peter J Robertson Journal: Otolaryngol Head Neck Surg Date: 2012-03 Impact factor: 3.497
Authors: G Conte; F M Lo Russo; S F Calloni; C Sina; S Barozzi; F Di Berardino; E Scola; G Palumbo; D Zanetti; F M Triulzi Journal: Acta Otorhinolaryngol Ital Date: 2018-08 Impact factor: 2.124
Authors: G Conte; S Casale; L Caschera; F M Lo Russo; C Paolella; C Cinnante; F Di Berardino; D Zanetti; D Stocchetti; E Scola; L Bassi; F Triulzi Journal: AJNR Am J Neuroradiol Date: 2021-01-28 Impact factor: 3.825
Authors: Marly F J A van der Lubbe; Akshayaa Vaidyanathan; Vincent Van Rompaey; Alida A Postma; Tjasse D Bruintjes; Dorien M Kimenai; Philippe Lambin; Marc van Hoof; Raymond van de Berg Journal: J Neurol Date: 2020-11-17 Impact factor: 4.849