D Cuesta-Frau1, P Miró-Martínez2, S Oltra-Crespo3, J Jordán-Núñez4, B Vargas5, L Vigil6. 1. Technological Institute of Informatics (ITI), Universitat Politècnica de València, Campus Alcoi (EPSA-UPV) Plaza Ferrándiz y Carbonell, 2, Alcoi, 03801, Spain. Electronic address: dcuesta@disca.upv.es. 2. Statistics Department at Universitat Politècnica de València, Campus Alcoi Plaza Ferrándiz y Carbonell, 2, Alcoi, 03801, Spain. Electronic address: pamimar@eio.upv.es. 3. Technological Institute of Informatics (ITI), Universitat Politècnica de València, Campus Alcoi (EPSA-UPV) Plaza Ferrándiz y Carbonell, 2, Alcoi, 03801, Spain. 4. Statistics Department at Universitat Politècnica de València, Campus Alcoi Plaza Ferrándiz y Carbonell, 2, Alcoi, 03801, Spain. 5. Internal Medicine Service at the University Hospital of Móstoles Río Júcar s/n, Móstoles, Madrid 28935, Spain. Electronic address: borja.vargas@salud.madrid.org. 6. Internal Medicine Service at the University Hospital of Móstoles Río Júcar s/n, Móstoles, Madrid 28935, Spain.
Abstract
BACKGROUND AND OBJECTIVES: The adoption in clinical practice of electronic portable blood or interstitial glucose monitors has enabled the collection, storage, and sharing of massive amounts of glucose level readings. This availability of data opened the door to the application of a multitude of mathematical methods to extract clinical information not discernible with conventional visual inspection. The objective of this study is to assess the capability of Permutation Entropy (PE) to find differences between glucose records of healthy and potentially diabetic subjects. METHODS: PE is a mathematical method based on the relative frequency analysis of ordinal patterns in time series that has gained a lot of attention in the last years due to its simplicity, robustness, and performance. We study in this paper the applicability of this method to glucose records of subjects at risk of diabetes in order to assess the predictability value of this metric in this context. RESULTS: PE, along with some of its derivatives, was able to find significant differences between diabetic and non-diabetic patients from records acquired up to 3 years before the diagnosis. The quantitative results for PE were 3.5878 ± 0.3916 for the nondiabetic class, and 3.1564 ± 0.4166 for the diabetic class. With a classification accuracy higher than 70%, and by means of a Cox regression model, PE demonstrated that it is a very promising candidate as a risk stratification tool for continuous glucose monitoring. CONCLUSION: PE can be considered as a prospective tool for the early diagnosis of the glucoregulatory system.
BACKGROUND AND OBJECTIVES: The adoption in clinical practice of electronic portable blood or interstitial glucose monitors has enabled the collection, storage, and sharing of massive amounts of glucose level readings. This availability of data opened the door to the application of a multitude of mathematical methods to extract clinical information not discernible with conventional visual inspection. The objective of this study is to assess the capability of Permutation Entropy (PE) to find differences between glucose records of healthy and potentially diabetic subjects. METHODS:PE is a mathematical method based on the relative frequency analysis of ordinal patterns in time series that has gained a lot of attention in the last years due to its simplicity, robustness, and performance. We study in this paper the applicability of this method to glucose records of subjects at risk of diabetes in order to assess the predictability value of this metric in this context. RESULTS:PE, along with some of its derivatives, was able to find significant differences between diabetic and non-diabeticpatients from records acquired up to 3 years before the diagnosis. The quantitative results for PE were 3.5878 ± 0.3916 for the nondiabetic class, and 3.1564 ± 0.4166 for the diabetic class. With a classification accuracy higher than 70%, and by means of a Cox regression model, PE demonstrated that it is a very promising candidate as a risk stratification tool for continuous glucose monitoring. CONCLUSION:PE can be considered as a prospective tool for the early diagnosis of the glucoregulatory system.
Authors: David Cuesta-Frau; Juan Pablo Murillo-Escobar; Diana Alexandra Orrego; Edilson Delgado-Trejos Journal: Entropy (Basel) Date: 2019-04-10 Impact factor: 2.524