| Literature DB >> 30336346 |
Bárbara Silva1, José A Pereira2, Sara Cravo3, Ana Margarida Araújo4, Carla Fernandes5, Madalena M M Pinto3, Paula Guedes de Pinho4, Fernando Remião4.
Abstract
The enantioresolution of pentedrone and methylone was carried out at a multi-milligram scale by liquid chromatography on a Chiralpak AS® stationary phase. The excellent enantioresolution using this column allowed to collect highly pure enantiomeric fractions, achieving enantiomeric ratios higher than 98%. An overall recovery of 72% was achieved for pentedrone enantiomers and 80% for methylone. Furthermore, the absolute configuration of the enantiomers of both cathinones was determined for the first time by electronic circular dichroism (ECD) spectroscopy, with the aid of theoretical calculations, as (+)‑(S) and (-)‑(R)-pentedrone, and (-)‑(S) and (+)‑(R)‑methylone.Entities:
Keywords: Absolute configuration; Methylone; Multi-milligram enantioresolution; Pentedrone; Polysaccharide-based stationary phase; Synthetic cathinones
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Year: 2018 PMID： 30336346 DOI： 10.1016/j.jchromb.2018.10.002
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205