Literature DB >> 30335564

Interleukin-22, a potent target for treatment of non-autoimmune diseases.

Yue Zheng1,2,3,4, Tong Li2,3,4,5.   

Abstract

Interleukin -22 (IL-22) is a member of interleukin-10 (IL-10) family cytokines that is produced by different types of lymphocytes included in both innate and adaptive immune systems. These lymphocytes include activated T cells, most notably Th17 and Th22 cells, as well as NK cells, γδ T cells, etc. IL-22 mediate its effects via the IL-22-IL-22R complex and subsequent Janus Kinase-signal transduces and activators transcription (JAK-STAT) signaling pathway. According to recent evidence, IL-22 played a critical role in the pathogenesis of many non-autoimmune diseases. In this review, we mainly discussed the recent findings and advancements of the role of IL-22 in several non-autoimmune diseases, such as acute lung injury, atherosclerosis and some bacterial infections, suggesting that IL-22 may have therapeutic potential for treating non-autoimmune diseases.

Entities:  

Keywords:  Interleukin-22; disease treatment; interleukin-10; non-autoimmune diseases

Year:  2018        PMID： 30335564      PMCID： PMC6343613          DOI： 10.1080/21645515.2018.1509649

Source DB:  PubMed          Journal:  Hum Vaccin Immunother        ISSN： 2164-5515            Impact factor:   3.452


  80 in total

1.  Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes.

Authors:  Heiko Methe; Stefan Brunner; Daniela Wiegand; Michael Nabauer; Joerg Koglin; Elazer R Edelman
Journal:  J Am Coll Cardiol       Date:  2005-06-21       Impact factor: 24.094

2.  Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages.

Authors:  Laurie E Harrington; Robin D Hatton; Paul R Mangan; Henrietta Turner; Theresa L Murphy; Kenneth M Murphy; Casey T Weaver
Journal:  Nat Immunol       Date:  2005-10-02       Impact factor: 25.606

3.  Patients with cystic fibrosis have inducible IL-17+IL-22+ memory cells in lung draining lymph nodes.

Authors:  Yvonne R Chan; Kong Chen; Steven R Duncan; Kira L Lathrop; Joseph D Latoche; Alison J Logar; Derek A Pociask; Brendon J Wahlberg; Prabir Ray; Anuradha Ray; Joseph M Pilewski; Jay K Kolls
Journal:  J Allergy Clin Immunol       Date:  2012-07-11       Impact factor: 10.793

4.  IL-22-producing Th22 cells play a protective role in CVB3-induced chronic myocarditis and dilated cardiomyopathy by inhibiting myocardial fibrosis.

Authors:  Yujie Guo; Weifeng Wu; Zhihong Cen; Xiaomo Li; Qing Kong; Qiuxi Zhou
Journal:  Virol J       Date:  2014-12-30       Impact factor: 4.099

5.  IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection.

Authors:  P Kumar; M S Thakar; W Ouyang; S Malarkannan
Journal:  Mucosal Immunol       Date:  2012-06-27       Impact factor: 7.313

6.  Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.

Authors:  J C J Martin; G Bériou; M Heslan; C Chauvin; L Utriainen; A Aumeunier; C L Scott; A Mowat; V Cerovic; S A Houston; M Leboeuf; F X Hubert; C Hémont; M Merad; S Milling; R Josien
Journal:  Mucosal Immunol       Date:  2013-05-08       Impact factor: 7.313

7.  JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury.

Authors:  Wei Ren; Zhiwei Wang; Zhiyong Wu; Zhipeng Hu; Feifeng Dai; Jinxing Chang; Bowen Li; Huagang Liu; Yongle Ruan
Journal:  Dis Markers       Date:  2017-07-30       Impact factor: 3.434

Review 8.  Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis.

Authors:  Leonie Brockmann; Anastasios D Giannou; Nicola Gagliani; Samuel Huber
Journal:  Int J Mol Sci       Date:  2017-05-11       Impact factor: 5.923

9.  Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis.

Authors:  Minrui Liang; Jiucun Wang; Haiyan Chu; Xiaoxia Zhu; Hang He; Qiong Liu; Jianhua Qiu; Xiaodong Zhou; Ming Guan; Yu Xue; Xiangjun Chen; Hejian Zou
Journal:  Mediators Inflamm       Date:  2013-02-18       Impact factor: 4.711

10.  IL-22 contributes to TGF-β1-mediated epithelial-mesenchymal transition in asthmatic bronchial epithelial cells.

Authors:  Jill R Johnson; Michiyoshi Nishioka; Jamila Chakir; Paul-André Risse; Ibrahim Almaghlouth; Ahmad N Bazarbashi; Sophie Plante; James G Martin; David Eidelman; Qutayba Hamid
Journal:  Respir Res       Date:  2013-11-01
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  3 in total

1.  Prurigo Nodularis Is Characterized by Systemic and Cutaneous T Helper 22 Immune Polarization.

Authors:  Micah Belzberg; Martin Prince Alphonse; Isabelle Brown; Kyle A Williams; Raveena Khanna; Byron Ho; Shannon Wongvibulsin; Thomas Pritchard; Youkyung Sophie Roh; Nishadh Sutaria; Justin Choi; Jaroslaw Jedrych; Andrew D Johnston; Kakali Sarkar; Chirag Vasavda; Jimmy Meixiong; Carly Dillen; Kent Bondesgaard; John F Paolini; Wei Chen; David Corcoran; Nicolas Devos; Madan M Kwatra; Anna L Chien; Nathan K Archer; Luis A Garza; Xinzhong Dong; Sewon Kang; Shawn G Kwatra
Journal:  J Invest Dermatol       Date:  2021-03-23       Impact factor: 7.590

2.  Systematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological analyses.

Authors:  Jing-Yi Hou; Jia-Rong Wu; Yi-Bing Chen; Dong Xu; Shu Liu; Dan-Dan Shang; Guan-Wei Fan; Yuan-Lu Cui
Journal:  Pharm Biol       Date:  2022-12       Impact factor: 3.503

Review 3.  Immunobiology of Atherosclerosis: A Complex Net of Interactions.

Authors:  Beatriz Herrero-Fernandez; Raquel Gomez-Bris; Beatriz Somovilla-Crespo; Jose Maria Gonzalez-Granado
Journal:  Int J Mol Sci       Date:  2019-10-24       Impact factor: 5.923
  3 in total

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