Yuki Tanabe1, Norihiro Harada1,2,3, Jun Ito1,2,4, Kei Matsuno1,2, Tomohito Takeshige1,2, Sonoko Harada1,2,3, Mirano Takemasa5, Masaki Kotajima5, Ayako Ishimori1, Yoko Katsura1, Fumihiko Makino1, Ryo Atsuta1, Kazuhisa Takahashi1,2. 1. a Department of Respiratory Medicine , Juntendo University Faculty of Medicine and Graduate School of Medicine , Tokyo , Japan. 2. b Research Institute for Diseases of Old Ages, Juntendo University Faculty of Medicine and Graduate School of Medicine , Tokyo , Japan. 3. c Atopy (Allergy) Research Center, Juntendo University Faculty of Medicine and Graduate School of Medicine , Tokyo , Japan. 4. d Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital , Kanagawa , Japan. 5. e Clinical Engineering Unit, Juntendo University Hospital , Tokyo , Japan.
Abstract
BACKGROUND: Fractional exhaled nitric oxide (FENO) is useful for the evaluation of eosinophilic airway inflammation, including that seen in asthma. Although a new electrochemical hand-held FENO analyzer, the NIOX VERO® (Aerocrine AB, Solna, Sweden), is clinically convenient to use, it has not been fully compared with the chemiluminescence stationary electrochemical analyzer NOA280i® (Sievers Instruments, Boulder, CO, USA) in terms of the level of measured FENO. The aim of this study was to determine whether there is a difference between the two analyzers. METHODS: The FENO levels measured with both NIOX VERO® and NOA280i® were evaluated in 1,369 adults at Juntendo University Hospital from May 2016 to October 2016. RESULTS: The median FENO level measured with the NIOX VERO® was significantly lower than that measured with the NOA280i® (41 ppb, range 5-368 ppb vs. 29 ppb, range 5-251 ppb; p < 0.001). There was a strong positive correlation in the measurement of FENO level between the NOA280i® and the NIOX VERO® (r = 0.942, p < 0.001). The following conversion equation was calculated: FENO (NOA280i®) = 1.362 (SE, 0.661) + 1.384 (SE, 0.021) × FENO (NIOX VERO®). CONCLUSIONS: To our best knowledge, we have provided the first report showing that the measured FENO level with the NIOX VERO® was approximately 30% lower than that with the NOA280i® and that there was a significant correlation between the measurements of these two devices. The correction equation that we provided may help assess the data obtained by these two analyzers. Abbreviations ATS American Thoracic Society BMI Body mass index ERS European Respiratory Society FENO Fractional exhaled nitric oxide GINA Global Initiative for Asthma NO Nitric oxide ppb Parts per billion ROC Receiver operating characteristic SD Standard deviation.
BACKGROUND: Fractional exhaled nitric oxide (FENO) is useful for the evaluation of eosinophilic airway inflammation, including that seen in asthma. Although a new electrochemical hand-held FENO analyzer, the NIOX VERO® (Aerocrine AB, Solna, Sweden), is clinically convenient to use, it has not been fully compared with the chemiluminescence stationary electrochemical analyzer NOA280i® (Sievers Instruments, Boulder, CO, USA) in terms of the level of measured FENO. The aim of this study was to determine whether there is a difference between the two analyzers. METHODS: The FENO levels measured with both NIOX VERO® and NOA280i® were evaluated in 1,369 adults at Juntendo University Hospital from May 2016 to October 2016. RESULTS: The median FENO level measured with the NIOX VERO® was significantly lower than that measured with the NOA280i® (41 ppb, range 5-368 ppb vs. 29 ppb, range 5-251 ppb; p < 0.001). There was a strong positive correlation in the measurement of FENO level between the NOA280i® and the NIOX VERO® (r = 0.942, p < 0.001). The following conversion equation was calculated: FENO (NOA280i®) = 1.362 (SE, 0.661) + 1.384 (SE, 0.021) × FENO (NIOX VERO®). CONCLUSIONS: To our best knowledge, we have provided the first report showing that the measured FENO level with the NIOX VERO® was approximately 30% lower than that with the NOA280i® and that there was a significant correlation between the measurements of these two devices. The correction equation that we provided may help assess the data obtained by these two analyzers. Abbreviations ATS American Thoracic Society BMI Body mass index ERS European Respiratory Society FENO Fractional exhaled nitric oxide GINA Global Initiative for Asthma NO Nitric oxide ppb Parts per billion ROC Receiver operating characteristic SD Standard deviation.
Authors: Tracy Coelho; Eva Sonnenberg-Riethmacher; Yifang Gao; Enrico Mossotto; Alisher Khojanazarov; Annie Griffin; Saida Mukanova; Aiymkul Ashimkhanova; Rachel Haggarty; Anton Borissenko; James J Ashton; Imogen S Stafford; Akshay Batra; Nadeem A Afzal; Michael P Stanton; Bhumita Vadgama; Kapura Adrisova; Robert M Beattie; Anthony P Williams; Sarah Ennis; Dieter Riethmacher Journal: Sci Rep Date: 2021-03-18 Impact factor: 4.379
Authors: Ran Wang; Stephen J Fowler; Stephen W Turner; Sarah Drake; Laura Healy; Lesley Lowe; Hannah Wardman; Miriam Bennett; Adnan Custovic; Angela Simpson; Clare S Murray Journal: ERJ Open Res Date: 2022-09-12