Hana Brath1,2, Nishila Mehta3,2, Rachel D Savage2, Sudeep S Gill4,5, Wei Wu2, Susan E Bronskill2,5,6, Lynn Zhu2, Jerry H Gurwitz7, Paula A Rochon2,6,8. 1. McMaster University, Hamilton, Ontario, Canada. 2. Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada. 3. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. 4. Department of Medicine, Queen's University, Kingston, Ontario, Canada. 5. Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. 6. Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada. 7. Division of Geriatric Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts. 8. Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Abstract
OBJECTIVES: To systematically describe the resources available on preventing, detecting, and reversing prescribing cascades using a scoping review methodology. MEASUREMENTS: We searched Medline, EMBASE, PsychINFO, CINAHL, Cochrane Library, and Sociological Abstracts from inception until July 2017. Other searches (Google Scholar, hand searches) and expert consultations were performed for resources examining how to prevent, detect, or reverse prescribing cascades. We used these three categories along the prescribing continuum as an organizing framework to categorize and synthesize resources. RESULTS: Of 369 resources identified, 58 met inclusion criteria; 29 of these were categorized as preventing, 20 as detecting, and 9 as reversing prescribing cascades. Resources originated from 14 countries and mostly focused on older adults. The goal of preventing resources was to educate and increase general awareness of the concept of prescribing cascades as a way to prevent inappropriate prescribing and to illustrate application of the concept to specific drugs (e.g., anticholinergics) and conditions (e.g., inflammatory bowel disease). Detecting resources included original investigations or case reports that identified prescribing cascades using health administrative data, patient cohorts, and novel sources such as social media. Reversing prescribing cascade resources focused on the medication review process and deprescribing initiatives. CONCLUSION: Prescribing cascades are a recognized problem internationally. By learning from the range of resources to prevent, detect, and reverse prescribing cascades, this review contributes to improving drug prescribing, especially in older adults. J Am Geriatr Soc 66:2079-2085, 2018.
OBJECTIVES: To systematically describe the resources available on preventing, detecting, and reversing prescribing cascades using a scoping review methodology. MEASUREMENTS: We searched Medline, EMBASE, PsychINFO, CINAHL, Cochrane Library, and Sociological Abstracts from inception until July 2017. Other searches (Google Scholar, hand searches) and expert consultations were performed for resources examining how to prevent, detect, or reverse prescribing cascades. We used these three categories along the prescribing continuum as an organizing framework to categorize and synthesize resources. RESULTS: Of 369 resources identified, 58 met inclusion criteria; 29 of these were categorized as preventing, 20 as detecting, and 9 as reversing prescribing cascades. Resources originated from 14 countries and mostly focused on older adults. The goal of preventing resources was to educate and increase general awareness of the concept of prescribing cascades as a way to prevent inappropriate prescribing and to illustrate application of the concept to specific drugs (e.g., anticholinergics) and conditions (e.g., inflammatory bowel disease). Detecting resources included original investigations or case reports that identified prescribing cascades using health administrative data, patient cohorts, and novel sources such as social media. Reversing prescribing cascade resources focused on the medication review process and deprescribing initiatives. CONCLUSION: Prescribing cascades are a recognized problem internationally. By learning from the range of resources to prevent, detect, and reverse prescribing cascades, this review contributes to improving drug prescribing, especially in older adults. J Am Geriatr Soc 66:2079-2085, 2018.
Authors: Shelley A Sternberg; Mirko Petrovic; Graziano Onder; Antonio Cherubini; Denis O'Mahony; Jerry H Gurwitz; Francesco Pegreffi; Robin Mason; Jennifer Akerman; Lisa McCarthy; Andrea Lawson; Joyce Li; Wei Wu; Paula A Rochon Journal: Eur Geriatr Med Date: 2021-04-09 Impact factor: 1.710
Authors: Sarah Bloomstone; Kathryn Anzuoni; Noelle Cocoros; Jerry H Gurwitz; Kevin Haynes; Vinit P Nair; Richard Platt; Paula A Rochon; Sonal Singh; Kathleen M Mazor Journal: Ther Adv Drug Saf Date: 2020-10-30
Authors: Shanna C Trenaman; Austin Harding; Susan K Bowles; Susan A Kirkland; Melissa K Andrew Journal: Front Pharmacol Date: 2022-06-22 Impact factor: 5.988
Authors: Rachel D Savage; Jessica D Visentin; Susan E Bronskill; Xuesong Wang; Andrea Gruneir; Vasily Giannakeas; Jun Guan; Kenneth Lam; Miles J Luke; Stephanie H Read; Nathan M Stall; Wei Wu; Lynn Zhu; Paula A Rochon; Lisa M McCarthy Journal: JAMA Intern Med Date: 2020-05-01 Impact factor: 21.873