BACKGROUND: Preclinical evidence from male subjects indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to reward-related stimuli. However, it is not known if exposure to the antidepressant fluoxetine, in female subjects specifically, changes sensitivity to natural and drug rewards, later in life. AIMS: The aim of this work was to investigate if exposure to fluoxetine mediates enduring changes in sensitivity to the rewarding properties of cocaine and sucrose, using female mice as a model system. METHODS: We exposed C57BL/6 female mice to fluoxetine (250 mg/L in their drinking water) for 15 consecutive days, either during adolescence (postnatal day 35-49) or adulthood (postnatal day 70-84). Twenty-one days later, mice were examined on their behavioral reactivity to cocaine (0, 2.5, 5, 7.5 mg/kg) using the conditioned place preference paradigm, or assessed on the two-bottle sucrose (1%) test. RESULTS: We found that regardless of age of antidepressant exposure, female mice pre-exposed to fluoxetine displayed reliable conditioning to the cocaine-paired compartment. However, when compared to respective age-matched controls, antidepressant pre-exposure decreased the magnitude of conditioning at the 5 and 7.5 mg/kg cocaine doses. Furthermore, fluoxetine pre-exposure reduced sucrose preference without altering total liquid intake. CONCLUSIONS: The data suggest that pre-exposure to fluoxetine, during adolescence or adulthood, results in a prolonged decrease in sensitivity to the rewarding properties of both natural and drug rewards in female C57BL/6 mice.
BACKGROUND: Preclinical evidence from male subjects indicates that exposure to psychotropic medications, during early development, results in long-lasting altered responses to reward-related stimuli. However, it is not known if exposure to the antidepressant fluoxetine, in female subjects specifically, changes sensitivity to natural and drug rewards, later in life. AIMS: The aim of this work was to investigate if exposure to fluoxetine mediates enduring changes in sensitivity to the rewarding properties of cocaine and sucrose, using female mice as a model system. METHODS: We exposed C57BL/6 female mice to fluoxetine (250 mg/L in their drinking water) for 15 consecutive days, either during adolescence (postnatal day 35-49) or adulthood (postnatal day 70-84). Twenty-one days later, mice were examined on their behavioral reactivity to cocaine (0, 2.5, 5, 7.5 mg/kg) using the conditioned place preference paradigm, or assessed on the two-bottle sucrose (1%) test. RESULTS: We found that regardless of age of antidepressant exposure, female mice pre-exposed to fluoxetine displayed reliable conditioning to the cocaine-paired compartment. However, when compared to respective age-matched controls, antidepressant pre-exposure decreased the magnitude of conditioning at the 5 and 7.5 mg/kg cocaine doses. Furthermore, fluoxetine pre-exposure reduced sucrose preference without altering total liquid intake. CONCLUSIONS: The data suggest that pre-exposure to fluoxetine, during adolescence or adulthood, results in a prolonged decrease in sensitivity to the rewarding properties of both natural and drug rewards in female C57BL/6 mice.
Authors: Alicia Izquierdo; Hilda Pozos; Adrianna De La Torre; Simone DeShields; James Cevallos; Jonathan Rodriguez; Alexandra Stolyarova Journal: Behav Brain Res Date: 2016-04-26 Impact factor: 3.332
Authors: Deanna L Wallace; Vincent Vialou; Loretta Rios; Tiffany L Carle-Florence; Sumana Chakravarty; Arvind Kumar; Danielle L Graham; Thomas A Green; Anne Kirk; Sergio D Iñiguez; Linda I Perrotti; Michel Barrot; Ralph J DiLeone; Eric J Nestler; Carlos A Bolaños-Guzmán Journal: J Neurosci Date: 2008-10-08 Impact factor: 6.167
Authors: Francisco J Flores-Ramirez; Lyonna F Parise; Jason B Alipio; Israel Garcia-Carachure; Samuel A Castillo; Minerva Rodriguez; Anapaula Themman; Omar Lira; Joshua Preciado-Piña; Sergio D Iñiguez Journal: J Affect Disord Date: 2019-02-19 Impact factor: 4.839
Authors: Daniela Franco; Jennifer Zamudio; Kennedy M Blevins; Eric A Núñez-Larios; Ulises M Ricoy; Sergio D Iñiguez; Arturo R Zavala Journal: Behav Brain Res Date: 2020-04-30 Impact factor: 3.332
Authors: Sergio D Iñiguez; Lyonna F Parise; Mary Kay Lobo; Francisco J Flores-Ramirez; Israel Garcia-Carachure; Brandon L Warren; Alfred J Robison Journal: Behav Neurosci Date: 2019-04 Impact factor: 1.912
Authors: Francisco J Flores-Ramirez; Anapaula Themann; Jorge A Sierra-Fonseca; Israel Garcia-Carachure; Samuel A Castillo; Minerva Rodriguez; Omar Lira; Joshua Preciado-Piña; Brandon L Warren; Alfred J Robison; Sergio D Iñiguez Journal: Sci Rep Date: 2021-04-08 Impact factor: 4.996