Giada Graziana Genchi1, Andrea Degl'Innocenti1, Alice Rita Salgarella2, Ilaria Pezzini2, Attilio Marino1, Arianna Menciassi2, Sara Piccirillo3, Michele Balsamo4, Gianni Ciofani1,5. 1. Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, Pontedera (Pisa) 56025, Italy. 2. Scuola Superiore Sant'Anna, The BioRobotics Institute, Viale Rinaldo Piaggio 34, Pontedera (Pisa) 56025, Italy. 3. Agenzia Spaziale Italiana, Via del Politecnico snc, Roma 00133, Italy. 4. Kayser Italia S.r.l., Via di Popogna 501, Livorno 57128, Italy. 5. Politecnico di Torino, Department of Aerospace & Mechanical Engineering, Corso Duca degli Abruzzi 24, Torino 10129, Italy.
Abstract
AIM: Oxidative stress (OS) is strictly associated with senescence/pathogenesis of biological systems. As putative countermeasure to environmental OS, cerium oxide nanoparticles (nanoceria [NC]) were administered to muscle cells on ground and aboard the International Space Station. MATERIALS & METHODS: Transcriptional analyses were conducted through microarray technology and hierarchical clustering. Venn diagram and gene ontology analyses were also performed on selected gene lists. RESULTS: Adaptive responses to both NC administration and to permanence in real microgravity conditions occurred. Enrichment in the biological processes related to aging, body fat development and mesodermal tissue proliferation for NC-treated samples were found. CONCLUSION: Nanotechnology antioxidants promise applications to pathological conditions governed by OS on Earth and in life-hostile environments (low Earth orbit and deep space).
AIM: Oxidative stress (OS) is strictly associated with senescence/pathogenesis of biological systems. As putative countermeasure to environmental OS, cerium oxide nanoparticles (nanoceria [NC]) were administered to muscle cells on ground and aboard the International Space Station. MATERIALS & METHODS: Transcriptional analyses were conducted through microarray technology and hierarchical clustering. Venn diagram and gene ontology analyses were also performed on selected gene lists. RESULTS: Adaptive responses to both NC administration and to permanence in real microgravity conditions occurred. Enrichment in the biological processes related to aging, body fat development and mesodermal tissue proliferation for NC-treated samples were found. CONCLUSION: Nanotechnology antioxidants promise applications to pathological conditions governed by OS on Earth and in life-hostile environments (low Earth orbit and deep space).
Authors: F Cristofaro; G Pani; B Pascucci; A Mariani; M Balsamo; A Donati; G Mascetti; G Rea; A M Rizzo; L Visai Journal: Sci Rep Date: 2019-11-20 Impact factor: 4.379
Authors: Alessandra Salvetti; Andrea Degl'Innocenti; Gaetana Gambino; Jack J W A van Loon; Chiara Ippolito; Sandra Ghelardoni; Eric Ghigo; Luca Leoncino; Mirko Prato; Leonardo Rossi; Gianni Ciofani Journal: J Biomed Mater Res A Date: 2021-05-07 Impact factor: 4.396