Literature DB >> 30332623

HMGB1: LPS Delivery Vehicle for Caspase-11-Mediated Pyroptosis.

Ho Min Kim1, You-Me Kim2.   

Abstract

Recognition of cytoplasmic lipopolysaccharide (LPS) by caspase-11 leads to pyroptosis and secretion of inflammatory mediators. In this issue of Immunity, Deng et al. (2018) report that high-mobility group box 1 (HMGB1) secreted by hepatocytes delivers extracellular LPS into the cytoplasm and mediates pyroptosis.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 30332623     DOI： 10.1016/j.immuni.2018.09.021

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  17 in total

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Review 10.  TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling.

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