Literature DB >> 3033139

A herpes simplex virus type 1 variant which fails to synthesize immediate early polypeptide VmwIE63.

A R MacLean, S M Brown.   

Abstract

We report the isolation of a variant (X2D) of herpes simplex virus type 1 strain 17 which has a deletion of 5 X 10(6) mol. wt. in the long unique and long inverted repeat regions, such that one copy of the immediate early (IE) gene 1 and two unique open reading frames coding for polypeptides of 20K and 22K are deleted. The mutant X2D synthesizes reduced levels of VmwIE110, and also apparently fails to synthesize VmwIE63, at both the protein and RNA levels, despite there being no apparent deletion in the coding or controlling regions of the IE2 gene. X2D also fails to synthesize the thymidine kinase polypeptide but exhibits normal growth characteristics in tissue culture.

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Year:  1987        PMID： 3033139     DOI： 10.1099/0022-1317-68-5-1339

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  9 in total

1.  Latent herpes simplex virus type 1 transcripts in peripheral and central nervous system tissues of mice map to similar regions of the viral genome.

Authors:  A M Deatly; J G Spivack; E Lavi; D R O'Boyle; N W Fraser
Journal:  J Virol       Date:  1988-03       Impact factor: 5.103

2.  Herpes simplex virus type 1 ICP27 deletion mutants exhibit altered patterns of transcription and are DNA deficient.

Authors:  A M McCarthy; L McMahan; P A Schaffer
Journal:  J Virol       Date:  1989-01       Impact factor: 5.103

3.  Expression of herpes simplex virus type 1 (HSV-1) latency-associated transcripts and transcripts affected by the deletion in avirulent mutant HFEM: evidence for a new class of HSV-1 genes.

Authors:  J G Spivack; N W Fraser
Journal:  J Virol       Date:  1988-09       Impact factor: 5.103

4.  Development of a regulatable oncolytic herpes simplex virus type 1 recombinant virus for tumor therapy.

Authors:  Feng Yao; Nao Murakami; Oliver Bleiziffer; Pengwei Zhang; Natali V Akhrameyeva; Ximing Xu; Richard Brans
Journal:  J Virol       Date:  2010-06-02       Impact factor: 5.103

5.  Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.

Authors:  M U Fareed; J G Spivack
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

6.  Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO.

Authors:  K L Jang; B Pulverer; J R Woodgett; D S Latchman
Journal:  Nucleic Acids Res       Date:  1991-09-25       Impact factor: 16.971

7.  The herpes simplex virus immediate-early protein ICP27 stimulates the transcription of cellular Alu repeated sequences by increasing the activity of transcription factor TFIIIC.

Authors:  K L Jang; D S Latchman
Journal:  Biochem J       Date:  1992-06-15       Impact factor: 3.857

8.  A HSV-1 variant (1720) generates four equimolar isomers despite a 9200-bp deletion from TRL and sequences between 9200 np and 97,000 np in inverted orientation being covalently bound to sequences 94,000-126,372 np.

Authors:  J Harland; S M Brown
Journal:  Virus Genes       Date:  1992-08       Impact factor: 2.332

9.  Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.

Authors:  J G Spivack; N W Fraser
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103
  9 in total

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