Literature DB >> 30329039

Genetics is the logic of life (at least of mine).

Reed B Wickner1.   

Abstract

I retrace my path from math to medicine to biochemistry to yeast genetics, my focus on infectious diseases of yeast and finally prions. My discovery of yeast prions relied on my particular focus on the logical relations of non-chromosomal genetic elements and the chromosomal genes involved in their propagation and expression. Pursuing an understanding of yeast prions involved structural biology based on genetics, solid-state NMR, population genetics and more genetics.

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Year:  2019        PMID: 30329039      PMCID: PMC6238109          DOI: 10.1093/femsyr/foy115

Source DB:  PubMed          Journal:  FEMS Yeast Res        ISSN: 1567-1356            Impact factor:   2.796


  8 in total

1.  Curing of the [URE3] prion by Btn2p, a Batten disease-related protein.

Authors:  Dmitry S Kryndushkin; Frank Shewmaker; Reed B Wickner
Journal:  EMBO J       Date:  2008-10-02       Impact factor: 11.598

Review 2.  Yeast prions: structure, biology, and prion-handling systems.

Authors:  Reed B Wickner; Frank P Shewmaker; David A Bateman; Herman K Edskes; Anton Gorkovskiy; Yaron Dayani; Evgeny E Bezsonov
Journal:  Microbiol Mol Biol Rev       Date:  2015-03       Impact factor: 11.056

3.  Amyloid of the prion domain of Sup35p has an in-register parallel beta-sheet structure.

Authors:  Frank Shewmaker; Reed B Wickner; Robert Tycko
Journal:  Proc Natl Acad Sci U S A       Date:  2006-12-14       Impact factor: 11.205

Review 4.  Prion domains: sequences, structures and interactions.

Authors:  Eric D Ross; Allen Minton; Reed B Wickner
Journal:  Nat Cell Biol       Date:  2005-11       Impact factor: 28.824

5.  Yeast prions [URE3] and [PSI+] are diseases.

Authors:  Toru Nakayashiki; Cletus P Kurtzman; Herman K Edskes; Reed B Wickner
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-15       Impact factor: 11.205

6.  Pol of gag-pol fusion protein required for encapsidation of viral RNA of yeast L-A virus.

Authors:  T Fujimura; J C Ribas; A M Makhov; R B Wickner
Journal:  Nature       Date:  1992-10-22       Impact factor: 49.962

7.  [URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae.

Authors:  R B Wickner
Journal:  Science       Date:  1994-04-22       Impact factor: 47.728

8.  Prion-inducing domain of yeast Ure2p and protease resistance of Ure2p in prion-containing cells.

Authors:  D C Masison; R B Wickner
Journal:  Science       Date:  1995-10-06       Impact factor: 47.728

  8 in total

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