Marceli Rocha Leite1, Dirce Maria Trevisan Zanetta2, Leila Antonangelo3, Lia Junqueira Marçal3, Dionei Ramos4, Emmanuel Almeida Burdmann5, Ubiratan Paula Santos6. 1. a Divisao de Pneumologia , Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil. 2. b Departamento de Epidemiologia , University of São Paulo Public Health School , São Paulo , Brazil. 3. c Laboratório de Investigação Médica 03 (LIM-03) - Departamento de Patologia, da Faculdade de Medicina FMUSP , Universidade de São Paulo , São Paulo , Brazil. 4. d Department of Physiotherapy , Universidade Estadual Paulista "Júlio de Mesquita Filho" Campus de Presidente Prudente , São Paulo , Brazil. 5. e Laboratório de Investigação Médica 12 (LIM-12), Divisão de Nefrologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina , Universidade de São Paulo , São Paulo , Brazil. 6. f Divisão de Pneumologia , Instituto do Coracao, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo , São Paulo , Brazil .
Abstract
Objective: To evaluate the effects of burnt sugarcane harvesting on the plasmatic and urinary concentrations of the club cell secretory protein (CC16) and inflammatory systemic biomarkers in a group of sugarcane cutters. Methods: Seventy-eight sugar cane workers were evaluated. The plasmatic and urinary concentrations of CC16, a pulmonary damage marker and inflammatory systemic biomarkers were collected at three time points: before, three months after and six months after the onset of the burnt sugarcane harvesting period. All evaluations were performed at ∼7 am, before the daily work shift. In the three-month evaluation, a post-work shift assessment (acute effect) was also performed. Results: The age of the workers was 37.9 ± 11.0 years. The PM2.5 concentrations were 27.0 (23.0-33.0) and 101.0 (31.0-139.5) µg/m3 in the pre harvest and harvest periods, respectively (p < .001). Burnt sugarcane harvesting was associated with a reduction, throughout the work during burnt sugarcane harvesting (subchronic effect), in plasmatic and urinary CC16 concentrations. Acutely, there was a decrease in plasmatic concentrations. There were acute and subchronic increases in inflammatory markers (neutrophils, monocytes) and muscle damage markers (CK and LDH) and a decrease in red blood cells. Conclusions: Harvesting of burnt sugarcane was associated with acute and subchronic reductions in the plasmatic and urinary concentrations of CC16 protein and changes in systemic inflammatory markers.
Objective: To evaluate the effects of burnt sugarcane harvesting on the plasmatic and urinary concentrations of the club cell secretory protein (CC16) and inflammatory systemic biomarkers in a group of sugarcane cutters. Methods: Seventy-eight sugar cane workers were evaluated. The plasmatic and urinary concentrations of CC16, a pulmonary damage marker and inflammatory systemic biomarkers were collected at three time points: before, three months after and six months after the onset of the burnt sugarcane harvesting period. All evaluations were performed at ∼7 am, before the daily work shift. In the three-month evaluation, a post-work shift assessment (acute effect) was also performed. Results: The age of the workers was 37.9 ± 11.0 years. The PM2.5 concentrations were 27.0 (23.0-33.0) and 101.0 (31.0-139.5) µg/m3 in the pre harvest and harvest periods, respectively (p < .001). Burnt sugarcane harvesting was associated with a reduction, throughout the work during burnt sugarcane harvesting (subchronic effect), in plasmatic and urinary CC16 concentrations. Acutely, there was a decrease in plasmatic concentrations. There were acute and subchronic increases in inflammatory markers (neutrophils, monocytes) and muscle damage markers (CK and LDH) and a decrease in red blood cells. Conclusions: Harvesting of burnt sugarcane was associated with acute and subchronic reductions in the plasmatic and urinary concentrations of CC16 protein and changes in systemic inflammatory markers.
Authors: Fumihiko Sasai; Keegan L Rogers; David J Orlicky; Arthur Stem; Joshua Schaeffer; Gabriela Garcia; Jacob Fox; Matthew S Ray; Jaime Butler-Dawson; Marvin Gonzalez-Quiroz; Ricardo Leiva; Gangadhar Taduri; Sirirat Anutrakululchai; Vidhya Venugopal; Magdalena Madero; Jason Glaser; Julia Wijkstrom; Annika Wernerson; Jared M Brown; Richard J Johnson; Carlos A Roncal-Jimenez Journal: Am J Physiol Renal Physiol Date: 2022-05-30