Literature DB >> 30328461

Synthesis of benzimidazoles by CuI-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde in water.

Fang Ke1, Peng Zhang, Chen Lin, Xiaoyan Lin, Jianhua Xu, Xiangge Zhou.   

Abstract

An efficient copper-catalyzed three-component reaction of 2-haloaniline, ammonia and aldehyde for the synthesis of benzimidazoles with 1,10-phenanthroline as the ligand has been developed. A variety of substituted benzimidazole derivatives can be obtained in yields up to 95%.

Entities:  

Year:  2018        PMID: 30328461     DOI: 10.1039/c8ob02172d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

Review 1.  Metal-Promoted Heterocyclization: A Heterosynthetic Approach to Face a Pandemic Crisis.

Authors:  Federico Vittorio Rossi; Dario Gentili; Enrico Marcantoni
Journal:  Molecules       Date:  2021-04-29       Impact factor: 4.411

2.  Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazines via Fe-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source.

Authors:  Jiang Xiao; Shuang Ren; Qiang Liu
Journal:  RSC Adv       Date:  2020-06-09       Impact factor: 3.361

  2 in total

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