Gin S Malhi1,2,3,4, Lauren Irwin1,2,3,4, Amber Hamilton1,2,3,4, Grace Morris1,2,3,4, Philip Boyce1,5, Roger Mulder1,6, Richard J Porter1,6. 1. Sophisticated Mood Appraisal & Refinement of Treatment (SMART) Group. 2. Academic Department of Psychiatry, Northern Sydney Local Health District, St Leonards, NSW, Australia. 3. Sydney Medical School Northern, University of Sydney, Sydney, NSW, Australia. 4. CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia. 5. Discipline of Psychiatry, Sydney Medical School, Westmead Clinical School, University of Sydney, Sydney, NSW, Australia. 6. Department of Psychological Medicine, University of Otago - Christchurch, Christchurch, New Zealand.
Abstract
OBJECTIVES: The treatment of mood disorders remains sub-optimal. A major reason for this is our lack of understanding of the underlying pathophysiology of depression and bipolar disorder. A core problem is the lack of specificity of our current diagnoses. This paper discusses the history of this problem and posits a solution in the form of a more sophisticated model. METHOD: The authors review the notable historical works that laid the foundations of mood disorder nosology; discuss the more recent influences that shaped modern diagnoses; and examine the evidence that mood disorders are characterised by multidimensional and longitudinal symptom profiles. RESULTS: The ACE model considers mood disorders as a combination of symptoms across three domains: Activity, Cognition, and Emotion; that vary over time. This multidimensional and longitudinal perspective is consistent with the prevalence of complex clinical presentations, such as mixed states, and highlights the importance of recurrence in mood disorders. CONCLUSIONS: The ACE model encourages researchers to characterise patients from a number of equally important perspectives and, by doing so, add specificity to the treatment of mood disorders.
OBJECTIVES: The treatment of mood disorders remains sub-optimal. A major reason for this is our lack of understanding of the underlying pathophysiology of depression and bipolar disorder. A core problem is the lack of specificity of our current diagnoses. This paper discusses the history of this problem and posits a solution in the form of a more sophisticated model. METHOD: The authors review the notable historical works that laid the foundations of mood disorder nosology; discuss the more recent influences that shaped modern diagnoses; and examine the evidence that mood disorders are characterised by multidimensional and longitudinal symptom profiles. RESULTS: The ACE model considers mood disorders as a combination of symptoms across three domains: Activity, Cognition, and Emotion; that vary over time. This multidimensional and longitudinal perspective is consistent with the prevalence of complex clinical presentations, such as mixed states, and highlights the importance of recurrence in mood disorders. CONCLUSIONS: The ACE model encourages researchers to characterise patients from a number of equally important perspectives and, by doing so, add specificity to the treatment of mood disorders.
Authors: Ludovico Mineo; Alessandro Rodolico; Giorgio Alfredo Spedicato; Andrea Aguglia; Simone Bolognesi; Carmen Concerto; Alessandro Cuomo; Arianna Goracci; Giuseppe Maina; Andrea Fagiolini; Mario Amore; Eugenio Aguglia Journal: Eur Psychiatry Date: 2022-05-31 Impact factor: 7.156
Authors: Alfredo B Cuéllar-Barboza; Susan L McElroy; Marin Veldic; Balwinder Singh; Simon Kung; Francisco Romo-Nava; Nicolas A Nunez; Alejandra Cabello-Arreola; Brandon J Coombes; Miguel Prieto; Hannah K Betcher; Katherine M Moore; Stacey J Winham; Joanna M Biernacka; Mark A Frye Journal: Int J Bipolar Disord Date: 2020-07-04