Ahmed Aber1, Aoife Howard2, Helen Buckley Woods2, Georgina Jones2,3, Jonathan Michaels2. 1. School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. a.aber@sheffield.ac.uk. 2. School of Health and Related Research, University of Sheffield, Regent Court, 30 Regent Street, Sheffield, S1 4DA, UK. 3. Department of Psychology, School of Social Sciences, Leeds Beckett University, Leeds, LS1 9HE, UK.
Abstract
OBJECTIVES: The aim of this study was to identify themes that determine health-related quality of life (HRQoL) in patients with carotid artery stenosis and identify the patient-reported outcome measures (PROMs) that best cover the identified themes. METHODS: A systematic review of the main six databases from inception to September 2018 was undertaken to identify primary qualitative studies reporting on the HRQoL of patients with carotid artery stenosis. The quality of studies was assessed using the Critical Appraisal Skills Programme (CASP) criteria. Findings from the included studies were analysed using framework analysis methodology. The identified themes were mapped against the items/domains from the PROMs used previously in patients with carotid artery stenosis. RESULTS: The systematic review identified four papers that fulfilled the inclusion criteria. The included papers reported the views of 62 patients with symptomatic carotid artery stenosis; 24 of the patients were awaiting assessment for intervention, 26 had carotid endarterectomy, and 12 were turned down for intervention and received best medical therapy. The overall quality of the included studies was good based on CASP criteria. Framework analysis identified 16 themes that were divided into five main domains: anxiety, impact on personal roles and activities, effect on independence, psychological impact, and symptoms. The best-fit generic and disease-specific PROMs were the Medical Outcomes Study 36-Item Short Form (SF-36®) and the Carotid Stenosis Specific Outcome Measure (CSSOM), respectively. None of the PROMs covered all the themes identified in the qualitative systematic review. CONCLUSION: The findings from the review identified the important themes that affect patients with carotid stenosis disease. The current generic and disease-specific PROMs do not cover all themes that impact the HRQoL of patients suffering with this disease. The proposed themes can be used to develop a new disease-specific PROM to measure HRQoL.
OBJECTIVES: The aim of this study was to identify themes that determine health-related quality of life (HRQoL) in patients with carotid artery stenosis and identify the patient-reported outcome measures (PROMs) that best cover the identified themes. METHODS: A systematic review of the main six databases from inception to September 2018 was undertaken to identify primary qualitative studies reporting on the HRQoL of patients with carotid artery stenosis. The quality of studies was assessed using the Critical Appraisal Skills Programme (CASP) criteria. Findings from the included studies were analysed using framework analysis methodology. The identified themes were mapped against the items/domains from the PROMs used previously in patients with carotid artery stenosis. RESULTS: The systematic review identified four papers that fulfilled the inclusion criteria. The included papers reported the views of 62 patients with symptomatic carotid artery stenosis; 24 of the patients were awaiting assessment for intervention, 26 had carotid endarterectomy, and 12 were turned down for intervention and received best medical therapy. The overall quality of the included studies was good based on CASP criteria. Framework analysis identified 16 themes that were divided into five main domains: anxiety, impact on personal roles and activities, effect on independence, psychological impact, and symptoms. The best-fit generic and disease-specific PROMs were the Medical Outcomes Study 36-Item Short Form (SF-36®) and the Carotid Stenosis Specific Outcome Measure (CSSOM), respectively. None of the PROMs covered all the themes identified in the qualitative systematic review. CONCLUSION: The findings from the review identified the important themes that affect patients with carotid stenosis disease. The current generic and disease-specific PROMs do not cover all themes that impact the HRQoL of patients suffering with this disease. The proposed themes can be used to develop a new disease-specific PROM to measure HRQoL.
Authors: Leo H Bonati; Joanna Dobson; Ale Algra; Alain Branchereau; Gilles Chatellier; Gustav Fraedrich; Willem P Mali; Hermann Zeumer; Martin M Brown; Jean-Louis Mas; Peter A Ringleb Journal: Lancet Date: 2010-09-15 Impact factor: 79.321
Authors: Munira Essat; Ahmed Aber; Patrick Phillips; Edith Poku; Helen Buckley Woods; Aoife Howard; Simon Palfreyman; Eva Kaltenthaler; Georgina Jones; Jonathan Michaels Journal: Ann Vasc Surg Date: 2018-03-06 Impact factor: 1.466
Authors: Ramon Luengo-Fernandez; Alastair M Gray; Linda Bull; Sarah Welch; Fiona Cuthbertson; Peter M Rothwell Journal: Neurology Date: 2013-10-09 Impact factor: 9.910
Authors: Ahmed Aber; Patrick Phillips; Elizabeth Lumley; Stephen Radley; Steven M Thomas; Shah Nawaz; Georgina Jones; Jonathan Michaels Journal: BMJ Open Date: 2020-08-11 Impact factor: 2.692