Literature DB >> 3032806

Effects of some prostaglandins and leukotrienes on lymphocytes, monocytes and their activity in vitro.

J Wasserman, S Hammarström, B Petrini, H Blomgren, L V von Stedingk, I Vedin.   

Abstract

The effect of some prostaglandins (PGs) and leukotrienes (LTs) on lymphocytes and monocytes was tested in vitro. Overnight incubation with PGD2 reduces the expression of Leu-2 antigen (suppressor/cytotoxic phenotype) and of Fc receptors for IgG. PGA2, PGD2 and to a lesser extent PGE2 inhibit PHA reactivity of lymphocytes. LTB4 does not have any inhibitory activity. Preincubation of lymphocytes with PGD2 and PGE2 decreases their NK activity. LTB4, but not the PGs tested, stimulates monocyte metabolism as assessed by chemiluminescence.

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Year:  1987        PMID： 3032806     DOI： 10.1159/000234328

Source DB:  PubMed          Journal:  Int Arch Allergy Appl Immunol        ISSN： 0020-5915


  3 in total

1.  Reduced prostaglandin F2 alpha release from blood mononuclear leukocytes after oral supplementation of omega3 fatty acids: the OmegAD study.

Authors:  Inger Vedin; Tommy Cederholm; Yvonne Freund-Levi; Hans Basun; Erik Hjorth; Gerd Faxén Irving; Maria Eriksdotter-Jönhagen; Marianne Schultzberg; Lars-Olof Wahlund; Jan Palmblad
Journal:  J Lipid Res       Date:  2009-11-24       Impact factor: 5.922

2.  Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors.

Authors:  J Wasserman; H Blomgren; S Rotstein; B Petrini; S Hammarström
Journal:  Bull N Y Acad Med       Date:  1989-01

Review 3.  Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells.

Authors:  Y Kikuchi; T Kita; J Hirata; M Fukushima
Journal:  Cancer Metastasis Rev       Date:  1994-12       Impact factor: 9.264
  3 in total

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