C Denkert1,2, S Loibl3, J Budczies4,5, S Wienert4,6, F Klauschen4. 1. Institut für Pathologie der Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. carsten.denkert@charite.de. 2. Deutsches Konsortium für Translationale Krebsforschung (DKTK), Standort Berlin, Berlin, Deutschland. carsten.denkert@charite.de. 3. German Breast Group, Neu-Isenburg, Deutschland. 4. Institut für Pathologie der Charité, Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland. 5. Institut für Pathologie, Universität Heidelberg, Heidelberg, Deutschland. 6. VMscope GmbH, Berlin, Deutschland.
Abstract
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have been identified as prognostic parameter in breast cancer. OBJECTIVES: The aim of this review article is to provide an overview on the clinical and analytical validation of TILs in breast cancer. MATERIALS AND METHODS: Summary of international guidelines of the TIL working group as well as clinical and translational studies. RESULTS, CONCLUSIONS: Breast carcinomas with a high TIL level have an improved response to neoadjuvant chemotherapy. Triple-negative and HER2-positive carcinomas with increased TIL levels have improved survival. TILs are a new prognostic biomarker for routine histopathological diagnosis.
BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have been identified as prognostic parameter in breast cancer. OBJECTIVES: The aim of this review article is to provide an overview on the clinical and analytical validation of TILs in breast cancer. MATERIALS AND METHODS: Summary of international guidelines of the TIL working group as well as clinical and translational studies. RESULTS, CONCLUSIONS: Breast carcinomas with a high TIL level have an improved response to neoadjuvant chemotherapy. Triple-negative and HER2-positive carcinomas with increased TIL levels have improved survival. TILs are a new prognostic biomarker for routine histopathological diagnosis.
Entities:
Keywords:
Biomarkers; Breast neoplasms; Immune infiltrate; Neoadjuvant therapy; Prognosis
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