Bile duct abnormalities in the acquired immune deficiency syndrome.

Pathological changes in the liver have been described in patients with acquired immune deficiency syndrome; however, lesions of the bile ducts have not been noted. We report 2 patients with intrahepatic bile duct abnormalities, one having sclerosing cholangitis of the large ducts. We discuss the possibility that these changes are secondary to opportunistic infection or are induced more directly by immunologic mechanisms.