Literature DB >> 30325856

Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis: Summary of the Working Group on Drug Development and Trials in Acute Pancreatitis at the National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Maisam Abu-El-Haija, Anna S Gukovskaya, Dana K Andersen1, Timothy B Gardner2, Peter Hegyi, Stephen J Pandol3, Georgios I Papachristou, Ashok K Saluja4, Vikesh K Singh5, Aliye Uc6, Bechien U Wu7.   

Abstract

A workshop was sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases to focus on research gaps and opportunities on drug development for pancreatitis. This conference was held on July 25, 2018, and structured into 3 working groups (WG): acute pancreatitis (AP) WG, recurrent AP WG, and chronic pancreatitis WG. This article reports the outcome of the work accomplished by the AP WG to provide the natural history, epidemiology, and current management of AP; inform about the role of preclinical models in therapy selection; and discuss clinical trial designs with clinical and patient-reported outcomes to test new therapies.

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Year:  2018        PMID: 30325856      PMCID: PMC6692135          DOI: 10.1097/MPA.0000000000001175

Source DB:  PubMed          Journal:  Pancreas        ISSN: 0885-3177            Impact factor:   3.327


  99 in total

1.  Acute hemorrhagic pancreatitis (massive necrosis) with fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet.

Authors:  B Lombardi; L W Estes; D S Longnecker
Journal:  Am J Pathol       Date:  1975-06       Impact factor: 4.307

2.  The changing incidence of acute pancreatitis in children: a single-institution perspective.

Authors:  M James Lopez
Journal:  J Pediatr       Date:  2002-05       Impact factor: 4.406

3.  Double blind, randomised, placebo controlled study of a platelet activating factor antagonist, lexipafant, in the treatment and prevention of organ failure in predicted severe acute pancreatitis.

Authors:  C D Johnson; A N Kingsnorth; C W Imrie; M J McMahon; J P Neoptolemos; C McKay; S K Toh; P Skaife; P C Leeder; P Wilson; M Larvin; L D Curtis
Journal:  Gut       Date:  2001-01       Impact factor: 23.059

4.  Vacuolar ATPase regulates zymogen activation in pancreatic acini.

Authors:  Stephen D Waterford; Thomas R Kolodecik; Edwin C Thrower; Fred S Gorelick
Journal:  J Biol Chem       Date:  2004-12-06       Impact factor: 5.157

5.  Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis.

Authors:  R Mofidi; M D Duff; S J Wigmore; K K Madhavan; O J Garden; R W Parks
Journal:  Br J Surg       Date:  2006-06       Impact factor: 6.939

6.  Dynamic nature of early organ dysfunction determines outcome in acute pancreatitis.

Authors:  A Buter; C W Imrie; C R Carter; S Evans; C J McKay
Journal:  Br J Surg       Date:  2002-03       Impact factor: 6.939

7.  Acute pancreatitis in children.

Authors:  John R DeBanto; Praveen S Goday; Martha R A Pedroso; Rehan Iftikhar; Ali Fazel; Sanjay Nayyar; Darwin L Conwell; Mark T Demeo; Frank R Burton; David C Whitcomb; Charles D Ulrich; Lawrence K Gates
Journal:  Am J Gastroenterol       Date:  2002-07       Impact factor: 10.864

Review 8.  L-arginine-induced experimental pancreatitis.

Authors:  Péter Hegyi; Zoltán Rakonczay; Réka Sári; Csaba Góg; János Lonovics; Tamás Takács; László Czakó
Journal:  World J Gastroenterol       Date:  2004-07-15       Impact factor: 5.742

9.  Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis.

Authors:  C D Johnson; M Abu-Hilal
Journal:  Gut       Date:  2004-09       Impact factor: 23.059

10.  Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic secretagogue.

Authors:  M Lampel; H F Kern
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1977-03-11
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  10 in total

Review 1.  Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders.

Authors:  Anna S Gukovskaya; Fred S Gorelick; Guy E Groblewski; Olga A Mareninova; Aurelia Lugea; Laura Antonucci; Richard T Waldron; Aida Habtezion; Michael Karin; Stephen J Pandol; Ilya Gukovsky
Journal:  Pancreas       Date:  2019-04       Impact factor: 3.327

2.  Tricetin Reduces Inflammation and Acinar Cell Injury in Cerulein-Induced Acute Pancreatitis: The Role of Oxidative Stress-Induced DNA Damage Signaling.

Authors:  Máté Nagy-Pénzes; Zoltán Hajnády; Zsolt Regdon; Máté Á Demény; Katalin Kovács; Tarek El-Hamoly; József Maléth; Péter Hegyi; Csaba Hegedűs; László Virág
Journal:  Biomedicines       Date:  2022-06-10

3.  Precision medicine for acute pancreatitis: current status and future opportunities.

Authors:  Rajarshi Mukherjee; Quentin Nunes; Wei Huang; Robert Sutton
Journal:  Precis Clin Med       Date:  2019-06-21

4.  Pancreas-specific deletion of protein kinase D attenuates inflammation, necrosis, and severity of acute pancreatitis.

Authors:  Jingzhen Yuan; Chintan Chheda; Honit Piplani; Meng Geng; Grace Tan; Reetu Thakur; Stephen J Pandol
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-10-09       Impact factor: 5.187

5.  Pancreatitis: TIGAR-O Version 2 Risk/Etiology Checklist With Topic Reviews, Updates, and Use Primers.

Authors:  David C Whitcomb
Journal:  Clin Transl Gastroenterol       Date:  2019-06       Impact factor: 4.488

6.  Spilanthol Inhibits Inflammatory Transcription Factors and iNOS Expression in Macrophages and Exerts Anti-inflammatory Effects in Dermatitis and Pancreatitis.

Authors:  Edina Bakondi; Salam Bhopen Singh; Zoltán Hajnády; Máté Nagy-Pénzes; Zsolt Regdon; Katalin Kovács; Csaba Hegedűs; Tamara Madácsy; József Maléth; Péter Hegyi; Máté Á Demény; Tibor Nagy; Sándor Kéki; Éva Szabó; László Virág
Journal:  Int J Mol Sci       Date:  2019-09-03       Impact factor: 5.923

7.  Kynurenic Acid and Its Analogue SZR-72 Ameliorate the Severity of Experimental Acute Necrotizing Pancreatitis.

Authors:  Zsolt Balla; Eszter Sára Kormányos; Balázs Kui; Emese Réka Bálint; Gabriella Fűr; Erik Márk Orján; Béla Iványi; László Vécsei; Ferenc Fülöp; Gabriella Varga; András Harazin; Vilmos Tubak; Mária A Deli; Csaba Papp; Attila Gácser; Tamara Madácsy; Viktória Venglovecz; József Maléth; Péter Hegyi; Lóránd Kiss; Zoltán Rakonczay
Journal:  Front Immunol       Date:  2021-10-21       Impact factor: 7.561

8.  Fentanyl but Not Morphine or Buprenorphine Improves the Severity of Necrotizing Acute Pancreatitis in Rats.

Authors:  Emese Réka Bálint; Gabriella Fűr; Balázs Kui; Zsolt Balla; Eszter Sára Kormányos; Erik Márk Orján; Brigitta Tóth; Gyöngyi Horváth; Edina Szűcs; Sándor Benyhe; Eszter Ducza; Petra Pallagi; József Maléth; Viktória Venglovecz; Péter Hegyi; Lóránd Kiss; Zoltán Rakonczay
Journal:  Int J Mol Sci       Date:  2022-01-21       Impact factor: 5.923

Review 9.  A Practical Approach to Management of Acute Pancreatitis: Similarities and Dissimilarities of Disease in Children and Adults.

Authors:  Zachary M Sellers; Monique T Barakat; Maisam Abu-El-Haija
Journal:  J Clin Med       Date:  2021-06-08       Impact factor: 4.241

10.  Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis.

Authors:  Tarek El-Hamoly; Zoltán Hajnády; Máté Nagy-Pénzes; Edina Bakondi; Zsolt Regdon; Máté A Demény; Katalin Kovács; Csaba Hegedűs; Sahar S Abd El-Rahman; Éva Szabó; József Maléth; Péter Hegyi; László Virág
Journal:  Int J Mol Sci       Date:  2021-03-30       Impact factor: 5.923

  10 in total

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