Sylvia E Badon1, Alyson J Littman1,2, Kwun Chuen Gary Chan3, Mahlet G Tadesse4, Patricia L Stapleton5, Theo K Bammler5, Tanya K Sorensen6, Michelle A Williams7, Daniel A Enquobahrie1. 1. Department of Epidemiology, University of Washington, Seattle, WA 98185, USA. 2. Seattle Epidemiologic Research & Information Center, VA Puget Sound, Seattle, WA 98108, USA. 3. Department of Biostatistics, University of Washington, Seattle, WA 98195, USA. 4. Department of Mathematics & Statistics, Georgetown University, Washington, DC 20057, USA. 5. Department of Occupational & Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA. 6. Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98104, USA. 7. Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA.
Abstract
AIM: Investigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92). RESULTS: Each additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (β = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (β = 0.084, 95% CI: 0.017-0.151). Each additional metabolic equivalent hour of early-pregnancy LTPA energy expenditure was associated with higher circulating miR-21-3p (β = 0.431, 95% CI: 0.089-0.772) in women carrying female offspring, and lower circulating miR-146b-5p (β = -0.285, 95% CI: -0.528 to -0.043) and miR-517-5p (β = -0.406, 95% CI: -0.736 to -0.076) in women carrying male offspring. CONCLUSION: Our findings suggest that LTPA may influence maternal epigenetic biomarkers, possibly in an offspring sex-specific manner.
AIM: Investigate associations of leisure time physical activity (LTPA) with DNA methylation and miRNAs during pregnancy. Patients & methods: LTPA, candidate DNA methylation and circulating miRNAs were measured (average 15 weeks gestation) in pregnant women (n = 92). RESULTS: Each additional hour of prepregnancy LTPA duration was associated with hypermethylation in C1orf212 (β = 0.137, 95% CI: 0.004-0.270) and higher circulating miR-146b-5p (β = 0.084, 95% CI: 0.017-0.151). Each additional metabolic equivalent hour of early-pregnancy LTPA energy expenditure was associated with higher circulating miR-21-3p (β = 0.431, 95% CI: 0.089-0.772) in women carrying female offspring, and lower circulating miR-146b-5p (β = -0.285, 95% CI: -0.528 to -0.043) and miR-517-5p (β = -0.406, 95% CI: -0.736 to -0.076) in women carrying male offspring. CONCLUSION: Our findings suggest that LTPA may influence maternal epigenetic biomarkers, possibly in an offspring sex-specific manner.
Entities:
Keywords:
DNA methylation; miRNA; peripheral blood; physical activity; pregnancy; sex-specific
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