Abnormal chromosomes including small metacentrics in 14 ovarian cancers.

In direct preparations of 14 ovarian cancers including 11 primary tumors, chromosomes #1 (12 tumors), #3 (12 tumors, including 3q- chromosomes in five), #6 [eight tumors, including six with a 6q- and two with an i(6p)], #11 (11p + in seven tumors), and #14 (14q+ in at least seven tumors) were most frequently involved in structural aberrations. Also, abnormal small metacentrics were seen in 11 tumors. In ten of these the chromosome appeared to be an i(4p) or i(5p) and in one of these, a mixed Müllerian tumor, there was also an i(12p); the latter anomaly was also present (in duplicate) in a dysgerminoma.