Literature DB >> 30323051

Comparison of Pharmacist-Directed Management of Multiplex PCR Blood Culture Results with Conventional Microbiology Methods on Effective and Optimal Therapy within a Community Hospital.

Allison M Porter1,2, Christopher M Bland3,2, Henry N Young2, David R Allen3, Sabrina R Croft3,2, R Ellen Gayheart4, Parks W Miller3, Rachel J Musgrove3, Emilee M Robertson3, Geneen M Gibson3,2.   

Abstract

Multiplex PCR combined with a pharmacist-driven reporting protocol was compared to the standard of care within a community hospital to evaluate initial changes after notification of a positive blood culture. The intervention group demonstrated decreased times to changes in antimicrobial therapy (P = 0.0081), increased changes to optimal antimicrobial therapy (P = 0.013), and decreased vancomycin use for coagulase-negative staphylococcus contaminants (P < 0.01) with multiplex PCR implementation and pharmacist intervention.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  community; mRDT; pharmacy; rapid diagnostic test; stewardship

Mesh：

Substances：

Year:  2018        PMID： 30323051      PMCID： PMC6325225          DOI： 10.1128/AAC.01575-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  6 in total

1.  Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.

Authors:  Anand Kumar; Daniel Roberts; Kenneth E Wood; Bruce Light; Joseph E Parrillo; Satendra Sharma; Robert Suppes; Daniel Feinstein; Sergio Zanotti; Leo Taiberg; David Gurka; Aseem Kumar; Mary Cheang
Journal:  Crit Care Med       Date:  2006-06       Impact factor: 7.598

2.  Assessment of impact of peptide nucleic acid fluorescence in situ hybridization for rapid identification of coagulase-negative staphylococci in the absence of antimicrobial stewardship intervention.

Authors:  Carol Holtzman; Dana Whitney; Tamar Barlam; Nancy S Miller
Journal:  J Clin Microbiol       Date:  2011-01-26       Impact factor: 5.948

3.  Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016.

Authors:  Andrew Rhodes; Laura E Evans; Waleed Alhazzani; Mitchell M Levy; Massimo Antonelli; Ricard Ferrer; Anand Kumar; Jonathan E Sevransky; Charles L Sprung; Mark E Nunnally; Bram Rochwerg; Gordon D Rubenfeld; Derek C Angus; Djillali Annane; Richard J Beale; Geoffrey J Bellinghan; Gordon R Bernard; Jean-Daniel Chiche; Craig Coopersmith; Daniel P De Backer; Craig J French; Seitaro Fujishima; Herwig Gerlach; Jorge Luis Hidalgo; Steven M Hollenberg; Alan E Jones; Dilip R Karnad; Ruth M Kleinpell; Younsuck Koh; Thiago Costa Lisboa; Flavia R Machado; John J Marini; John C Marshall; John E Mazuski; Lauralyn A McIntyre; Anthony S McLean; Sangeeta Mehta; Rui P Moreno; John Myburgh; Paolo Navalesi; Osamu Nishida; Tiffany M Osborn; Anders Perner; Colleen M Plunkett; Marco Ranieri; Christa A Schorr; Maureen A Seckel; Christopher W Seymour; Lisa Shieh; Khalid A Shukri; Steven Q Simpson; Mervyn Singer; B Taylor Thompson; Sean R Townsend; Thomas Van der Poll; Jean-Louis Vincent; W Joost Wiersinga; Janice L Zimmerman; R Phillip Dellinger
Journal:  Crit Care Med       Date:  2017-03       Impact factor: 7.598

4.  Benefits of Adding a Rapid PCR-Based Blood Culture Identification Panel to an Established Antimicrobial Stewardship Program.

Authors:  Shawn H MacVane; Frederick S Nolte
Journal:  J Clin Microbiol       Date:  2016-08-03       Impact factor: 5.948

Review 5.  The Effect of Molecular Rapid Diagnostic Testing on Clinical Outcomes in Bloodstream Infections: A Systematic Review and Meta-analysis.

Authors:  Tristan T Timbrook; Jacob B Morton; Kevin W McConeghy; Aisling R Caffrey; Eleftherios Mylonakis; Kerry L LaPlante
Journal:  Clin Infect Dis       Date:  2016-09-26       Impact factor: 9.079

6.  Impact of rapid organism identification via matrix-assisted laser desorption/ionization time-of-flight combined with antimicrobial stewardship team intervention in adult patients with bacteremia and candidemia.

Authors:  Angela M Huang; Duane Newton; Anjly Kunapuli; Tejal N Gandhi; Laraine L Washer; Jacqueline Isip; Curtis D Collins; Jerod L Nagel
Journal:  Clin Infect Dis       Date:  2013-07-29       Impact factor: 9.079
  6 in total
  4 in total

1.  No Implementation Without Representation: Real-Time Pharmacist Intervention Optimizes Rapid Diagnostic Tests for Bacteremia at a Small Community Hospital.

Authors:  Brandon J Tritle; Robert Watteyne; Abby Hickman; Todd J Vento; Bert K Lopansri; Dave S Collingridge; John J Veillette
Journal:  Hosp Pharm       Date:  2021-08-08

2.  Impact of Pharmacist Involvement on the Utility of a Gram-Negative Blood Culture Identification Panel on Antimicrobial Usage.

Authors:  Caitlin Bowman; Melissa Holloway; Lisa Scott; Carmen Russell; Sonia Lott; Raid Amin
Journal:  J Pharm Technol       Date:  2021-09-18

3.  Management of Gram-Negative Bloodstream Infections in the Era of Rapid Diagnostic Testing: Impact With and Without Antibiotic Stewardship.

Authors:  Kimberly C Claeys; Emily L Heil; Stephanie Hitchcock; J Kristie Johnson; Surbhi Leekha
Journal:  Open Forum Infect Dis       Date:  2020-09-12       Impact factor: 3.835

4.  A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2018.

Authors:  Elias B Chahine; Spencer H Durham; Krutika N Mediwala; Daniel B Chastain; Timothy P Gauthier; Brandon K Hill; Bruce M Jones; Jamie J Kisgen; Ashley H Marx; Kayla R Stover; Marylee V Worley; Christopher M Bland; P Brandon Bookstaver
Journal:  Open Forum Infect Dis       Date:  2019-10-15       Impact factor: 3.835
  4 in total

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