Jianye Liang1, Jun Guo2, Dexiang Liu3, Changzheng Shi4, Liangping Luo5. 1. Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address: ljyjnu@foxmail.com. 2. Medical Imaging Center, Guangdong Sanjiu Brain Hospital, Jinan University, Guangzhou, China. Electronic address: 1026037108@qq.com. 3. Department of Radiology, Panyu Central Hospital, Guangzhou, China. Electronic address: xiangmail3@21cn.com. 4. Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address: cshi17@jhmi.edu. 5. Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangzhou, China. Electronic address: tluolp@jnu.edu.cn.
Abstract
BACKGROUND: This study aimed to analyze the vascular wall and atherosclerotic plaques of the middle cerebral artery (MCA) and compare their differences between patients with cerebral infarction and transient ischemic attack (TIA) using 3-dimensional fast-spin-echo T1-weighted sequence (namely CUBE). METHODS: Forty-seven patients with atherosclerotic stenosis of the MCA were included in this study. They received magnetic resonance examinations with routine T1WI, T2WI, 3-dimensional time-of-flight magnetic resonance angiography and diffusion-weighted imaging, as well as high-resolution CUBE T1WI sequence. Two physicians independently observed the location and degree of enhancement of the atheromatous plaques. The vessel area and lumen area at the maximal-lumen-narrowing and reference site were measured to calculate the plaque area, rate of stenosis, and remodeling index of the MCA. The chi-squared test was used to compare the differences of degree of enhancement between the cerebral infarction and TIA groups. The differences of rate of stenosis and remodeling index were compared by independent sample t test. RESULTS: Twenty-five lesion vessels in the infarction group and 22 in the TIA group were analyzed. The difference of stenosis rate between the groups was not statistically significant. The lesion vessels of infarction group had a significantly larger remodeling index and plaque area, and the plaques had a significantly higher degree of enhancement, compared to the TIA group. CONCLUSIONS: CUBE T1WI can be used to characterize the MCA vessel wall and atherosclerotic plaque. Positive remodeling and enhanced plaques are closely correlated with the occurrence of brain stroke.
BACKGROUND: This study aimed to analyze the vascular wall and atherosclerotic plaques of the middle cerebral artery (MCA) and compare their differences between patients with cerebral infarction and transient ischemic attack (TIA) using 3-dimensional fast-spin-echo T1-weighted sequence (namely CUBE). METHODS: Forty-seven patients with atherosclerotic stenosis of the MCA were included in this study. They received magnetic resonance examinations with routine T1WI, T2WI, 3-dimensional time-of-flight magnetic resonance angiography and diffusion-weighted imaging, as well as high-resolution CUBE T1WI sequence. Two physicians independently observed the location and degree of enhancement of the atheromatous plaques. The vessel area and lumen area at the maximal-lumen-narrowing and reference site were measured to calculate the plaque area, rate of stenosis, and remodeling index of the MCA. The chi-squared test was used to compare the differences of degree of enhancement between the cerebral infarction and TIA groups. The differences of rate of stenosis and remodeling index were compared by independent sample t test. RESULTS: Twenty-five lesion vessels in the infarction group and 22 in the TIA group were analyzed. The difference of stenosis rate between the groups was not statistically significant. The lesion vessels of infarction group had a significantly larger remodeling index and plaque area, and the plaques had a significantly higher degree of enhancement, compared to the TIA group. CONCLUSIONS: CUBE T1WI can be used to characterize the MCA vessel wall and atherosclerotic plaque. Positive remodeling and enhanced plaques are closely correlated with the occurrence of brain stroke.
Authors: Jiayu Xiao; Matthew M Padrick; Tao Jiang; Shuang Xia; Fang Wu; Yu Guo; Nestor R Gonzalez; Shujuan Li; Konrad H Schlick; Oana M Dumitrascu; Marcel M Maya; Marcio A Diniz; Shlee S Song; Patrick D Lyden; Debiao Li; Qi Yang; Zhaoyang Fan Journal: Atherosclerosis Date: 2021-01-11 Impact factor: 5.162
Authors: Jae W Song; Athanasios Pavlou; Morgan P Burke; Haochang Shou; Kofi-Buaku Atsina; Jiayu Xiao; Laurie A Loevner; David Mankoff; Zhaoyang Fan; Scott E Kasner Journal: Neuroradiology Date: 2020-10-07 Impact factor: 2.995