Literature DB >> 3032185

Conservation of E6 and E7 regions of human papillomavirus types 16 and 18 present in cervical cancers.

N Takebe, Y Tsunokawa, S Nozawa, M Terada, T Sugimura.   

Abstract

The E6 and E7 regions of human papillomavirus (HPV) type 16 were present in the DNA samples from cervical cancer cell lines, SKG-IIIa and SKG-IIIb, and those from cervical cancer tissues of three different patients. T601 cells, an NIH3T3 transformant obtained by transfection of DNA from a surgical specimen of a cervical cancer, also contained the E6 and E7 regions. The E6 region of HPV type 16 was expressed as mRNA in SKG-IIIa, SKG-IIIb and T601 cells. The E6 and E7 regions of HPV type 18 were present in the DNA samples from cervical cancer cell lines, SKG-I and SKG-II, and those from cervical cancer tissues of two different patients. SKG-I and SKG-II cells expressed the E6 region of HPV type 18 as mRNAs. These results strongly suggest that the E6 and E7 regions or the sequence surrounding these regions are important for maintaining malignant phenotype of cervical cancer cells.

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Year:  1987        PMID： 3032185     DOI： 10.1016/0006-291x(87)90325-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Induction of anchorage-independent growth of human embryonic fibroblasts with a deletion in the short arm of chromosome 11 by human papillomavirus type 16 DNA.

Authors:  H L Smits; E Raadsheer; I Rood; S Mehendale; R M Slater; J van der Noordaa; J ter Schegget
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

2.  Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product.

Authors:  Y Imai; Y Matsushima; T Sugimura; M Terada
Journal:  J Virol       Date:  1991-09       Impact factor: 5.103

3.  Nucleotide sequences of cDNAs for human papillomavirus type 18 transcripts in HeLa cells.

Authors:  Y Inagaki; Y Tsunokawa; N Takebe; H Nawa; S Nakanishi; M Terada; T Sugimura
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

4.  Sequence duplication and internal deletion in the integrated human papillomavirus type 16 genome cloned from a cervical carcinoma.

Authors:  K B Choo; H H Lee; C C Pan; S M Wu; L N Liew; W F Cheung; S H Han
Journal:  J Virol       Date:  1988-05       Impact factor: 5.103

5.  Amplification of human papillomavirus type 16 transforming genes from cervical cancer biopsies and lymph nodes of Hungarian patients.

Authors:  J Czeglédy; R Póka; G Veress; L Gergely
Journal:  J Clin Microbiol       Date:  1992-01       Impact factor: 5.948

6.  Chromosomal insertion and amplification of human papillomavirus 16 DNA sequences in a cell line of argyrophil small cell carcinoma of the uterine cervix.

Authors:  T Hori; H Ichimura; M Minamihisamatsu; E Takahashi; M Yamauchi; Y Hama; O Kurimura; M Yamasaki; T Kurimura
Journal:  Jpn J Cancer Res       Date:  1991-04

7.  The potential of RNA as a target for national screening of pre-cancer.

Authors:  Frank Karlsen; Margaret Muturi; Cosmas Muyabwa; Lars E Roseng; Serge Bigabwa; Byamungu Chihongola; Lucy Muchiri
Journal:  J Public Health Afr       Date:  2018-12-21

8.  Human papillomavirus type 18 DNA and E6-E7 mRNA are detected in squamous cell carcinoma and adenocarcinoma of the lung.

Authors:  I Kinoshita; H Dosaka-Akita; M Shindoh; M Fujino; K Akie; M Kato; K Fujinaga; Y Kawakami
Journal:  Br J Cancer       Date:  1995-02       Impact factor: 7.640

9.  Serum antibody against unfused recombinant E7 protein of human papillomavirus type 16 in cervical cancer patients.

Authors:  T Fujii; Y Matsushima; M Yajima; T Sugimura; M Terada
Journal:  Jpn J Cancer Res       Date:  1995-01
  9 in total

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