Literature DB >> 3032100

Effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on viral DNA and protein synthesis in cells infected with herpes simplex virus.

Y S Chun, N H Park.   

Abstract

The effect of ganciclovir [9-(1,3-dihydroxy-2-propoxymethyl)guanine] on herpes simplex virus type 1 DNA and protein synthesis was studied. Ganciclovir markedly inhibited the synthesis of viral DNA and gamma proteins in a dose-dependent manner. However, the synthesis of viral beta proteins was significantly increased by ganciclovir in the later stage of infection.

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Year:  1987        PMID： 3032100      PMCID： PMC174725          DOI： 10.1128/AAC.31.2.349

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  THE MULTIPLICATION OF HERPES SIMPLEX VIRUS. II. THE RELATION BETWEEN PROTEIN SYNTHESIS AND THE DUPLICATION OF VIRAL DNA IN INFECTED HEP-2 CELLS.

Authors:  B ROIZMAN; P R ROANE
Journal:  Virology       Date:  1964-02       Impact factor: 3.616

2.  The synthesis of herpes simplex virus proteins in the absence of virus DNA synthesis.

Authors:  K L Powell; D J Purifoy; R J Courtney
Journal:  Biochem Biophys Res Commun       Date:  1975-09-02       Impact factor: 3.575

3.  Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides.

Authors:  R W Honess; B Roizman
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

4.  Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants.

Authors:  L S Morse; L Pereira; B Roizman; P A Schaffer
Journal:  J Virol       Date:  1978-05       Impact factor: 5.103

5.  A new method for the isolation of herpes simplex virus type 2 DNA.

Authors:  J M Walboomers; J T Schegget
Journal:  Virology       Date:  1976-10-01       Impact factor: 3.616

6.  Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell.

Authors:  R W Honess; B Roizman
Journal:  J Virol       Date:  1973-12       Impact factor: 5.103

7.  Activation by thymidine kinase and potent antiherpetic activity of 2'-nor-2'-deoxyguanosine (2'NDG).

Authors:  W T Ashton; J D Karkas; A K Field; R L Tolman
Journal:  Biochem Biophys Res Commun       Date:  1982-10-29       Impact factor: 3.575

8.  Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

Authors:  W H Miller; R L Miller
Journal:  J Biol Chem       Date:  1980-08-10       Impact factor: 5.157

9.  9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.

Authors:  A K Field; M E Davies; C DeWitt; H C Perry; R Liou; J Germershausen; J D Karkas; W T Ashton; D B Johnston; R L Tolman
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

10.  Effect of acyclovir on viral protein synthesis in cells infected with herpes simplex virus type 1.

Authors:  P A Furman; P V McGuirt
Journal:  Antimicrob Agents Chemother       Date:  1983-02       Impact factor: 5.191
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  2 in total

Review 1.  Ganciclovir. A review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy in cytomegalovirus infections.

Authors:  D Faulds; R C Heel
Journal:  Drugs       Date:  1990-04       Impact factor: 9.546

Review 2.  Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications.

Authors:  Timothy Y Chou; Bennett Y Hong
Journal:  Ther Clin Risk Manag       Date:  2014-08-20       Impact factor: 2.423
  2 in total

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