Literature DB >> 30320933

Prevalence and Cost Analysis of Chronic Pain After Hernia Repair: A Potential Alternative Approach With Neurostimulation.

Aladine A Elsamadicy1,2, Bilal Ashraf1, Xinru Ren3, Amanda R Sergesketter1, Lefko Charalambous1, Hanna Kemeny1, Tiffany Ejikeme1, Siyun Yang3, Promila Pagadala1, Beth Parente1, Jichun Xie3, Theodore N Pappas4, Shivanand P Lad1.   

Abstract

OBJECTIVES: Chronic pain (CP) affects a significant number of patients following hernia repair, ranging from 11 to 54% in the literature. The aim of this study was to assess the prevalence, overall costs, and health care utilization associated with CP after hernia repair.
MATERIALS AND METHODS: A retrospective longitudinal study was performed using the Truven MarketScan® data base to identify patients who develop chronic neuropathic posthernia repair pain from 2001 to 2012. Patients were grouped into CP and No Chronic Pain (No CP) cohorts. Patients were excluded if they 1) were under 18 years of age; 2) had a previous pain diagnosis; 3) had CP diagnosed <90 days after the index hernia repair; 4) had less than one year of follow-up; or 5) had less than one-year baseline record before hernia repair. Patients were grouped into the CP cohort if their CP diagnosis was made within the two years following index hernia repair. Total, outpatient, and pain prescription costs were collected in the period of five years prehernia to nine years posthernia repair. A longitudinal multivariate analysis was used to model the effects of chronic neuropathic posthernia repair pain on total inpatient/outpatient and pain prescription costs.
RESULTS: We identified 76,173 patients who underwent hernia repair and met inclusion criteria (CP: n = 14,919, No CP: n = 61,254). There was a trend for increased total inpatient/outpatient and pain prescription costs one-year posthernia repair, when compared to baseline costs for both cohorts. In both cohorts, total inpatient/outpatient costs remained elevated from baseline through nine years posthernia repair, with the CP cohort experiencing significantly higher cumulative median costs (CP: $51,334, No CP: $37,388). The CP diagnosis year was associated with a 1.75-fold increase (p < 0.001) in total inpatient/outpatient costs and a 2.26-fold increase (p < 0.001) in pain prescription costs versus all other years. In the longitudinal analysis, the CP cohort had a 1.14-fold increase (p < 0.001) in total inpatient/outpatient costs and 2.00-fold increase (p < 0.001) in pain prescription costs.
CONCLUSIONS: Our study demonstrates the prevalence of CP after hernia surgery to be nearly 20%, with significantly increased costs and healthcare resource utilization. While current treatment paradigms are effective for many, there remains a large number of patients that could benefit from an overall approach that includes nonopioid treatments, such as potentially incorporating neurostimulation, for CP that presents posthernia repair.
© 2018 International Neuromodulation Society.

Entities:  

Keywords:  Chronic pain; DRG stimulation; hernia repair; neuromodulation; peripheral nerve stimulation; spinal cord stimulation

Mesh:

Year:  2018        PMID: 30320933      PMCID: PMC6465156          DOI: 10.1111/ner.12871

Source DB:  PubMed          Journal:  Neuromodulation        ISSN: 1094-7159


  31 in total

Review 1.  Chronic pain after mesh repair of inguinal hernia: a systematic review.

Authors:  Simon Nienhuijs; Erik Staal; Luc Strobbe; Camiel Rosman; Hans Groenewoud; Rob Bleichrodt
Journal:  Am J Surg       Date:  2007-09       Impact factor: 2.565

2.  Current trends in the diagnosis and management of post-herniorraphy chronic groin pain.

Authors:  Abdul Hakeem; Venkatesh Shanmugam
Journal:  World J Gastrointest Surg       Date:  2011-06-27

3.  Pain and functional impairment 1 year after inguinal herniorrhaphy: a nationwide questionnaire study.

Authors:  M Bay-Nielsen; F M Perkins; H Kehlet
Journal:  Ann Surg       Date:  2001-01       Impact factor: 12.969

4.  Effect of intraoperative infiltration with local anesthesia on the development of chronic pain after inguinal hernia repair: a randomized, triple-blinded, placebo-controlled trial.

Authors:  Anita Kurmann; Henning Fischer; Salome Dell-Kuster; Rachel Rosenthal; Laurent Audigé; Guido Schüpfer; Jürg Metzger; Philipp Honigmann
Journal:  Surgery       Date:  2015-01       Impact factor: 3.982

5.  Clinical characteristics and economic costs of patients with painful neuropathic disorders.

Authors:  Ariel Berger; Ellen M Dukes; Gerry Oster
Journal:  J Pain       Date:  2004-04       Impact factor: 5.820

6.  Hernia repair: why do we continue to perform mesh repair in the face of the human toll of inguinodynia?

Authors:  Josef E Fischer
Journal:  Am J Surg       Date:  2013-07-17       Impact factor: 2.565

7.  The effects of gabapentin on acute and chronic pain after inguinal herniorrhaphy.

Authors:  Hüseyin Sen; Ali Sizlan; Omer Yanarateş; Mehmet Güney Senol; Gökhan Inangil; Ilker Sücüllü; Sezai Ozkan; Güner Dağli
Journal:  Eur J Anaesthesiol       Date:  2009-09       Impact factor: 4.330

Review 8.  A review of chronic pain after inguinal herniorrhaphy.

Authors:  Amudha S Poobalan; Julie Bruce; W Cairns S Smith; Peter M King; Zygmunt H Krukowski; W Alastair Chambers
Journal:  Clin J Pain       Date:  2003 Jan-Feb       Impact factor: 3.442

9.  Combined spinal cord and peripheral nerve field stimulation for persistent post-herniorrhaphy pain.

Authors:  Guilherme Lepski; Payman Vahedi; Marcos Soares Tatagiba; Matthias Morgalla
Journal:  Neuromodulation       Date:  2012-06-01

10.  Pain severity and the economic burden of neuropathic pain in the United States: BEAT Neuropathic Pain Observational Study.

Authors:  Caroline Schaefer; Alesia Sadosky; Rachael Mann; Shoshana Daniel; Bruce Parsons; Michael Tuchman; Alan Anschel; Brett R Stacey; Srinivas Nalamachu; Edward Nieshoff
Journal:  Clinicoecon Outcomes Res       Date:  2014-10-29
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