Hung-Chieh Wu1,2, Lin-Chien Lee3, Wei-Jie Wang1,4. 1. Division of Nephrology, Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan. 2. Institute of Public Health, National Yang Ming University, Taipei, Taiwan. 3. Department of Physical Medicine and Rehabilitation, Cheng Hsin General Hospital, Taipei, Taiwan. 4. Department of Biomedical Engineering, Chung Yuan Christian University, Taoyuan, Taiwan.
Abstract
OBJECTIVES: Several factors in double filtration plasmapheresis (DFPP) were associated with triglyceride (TG) clearance rate. This study examines whether baseline whole blood viscosity was a predictor for efficient TG removal. METHODS: Adult subjects who receiving DFPP for hyperlipidemia in Taoyuan General Hospital from January 2015 to March 2018 were classified into efficient and inefficient TG removal according to TG removal rate ≥50% vs <50%. TG removal rate was defined as following formula: (pre-apheresis TG- post-apheresis TG)/pre-apheresis TG. Whole blood viscosity (WBV) was estimated by following equation: WBV = 0.12 × hematocrit +0.17 × (total protein -2.07). Univariate linear regression was used to assess the association between TG removal rate and WBV. Odds ratios (ORs) and 95% confidence interval (95%CI) for associations between variables and efficient TG removal were evaluated by logistic regression model to including univariate and multivariate adjustment. RESULTS: From a total of 66 subjects receiving DFPP, 37 subjects reached efficient TG removal. The difference in pre-apheresis TG levels, hematocrit, and WBV between efficient vs. inefficient TG removal groups was 4.1 vs 6.7 mmol/L; 43.1% vs 39.5%; and 6.0cP vs 5.cP (Ps <0.05). After multivariate adjustment, WBC was a significant predictor for efficient TG removal (ORs and 95% CI were 3.192 (1.300-7.838), P < 0.05). The correlation between WBV and extraction of TG was significant (r = -0.255, P = 0.039). CONCLUSION: Hyperviscosity reduced the efficiency of TG removal in those receiving DFPP.
OBJECTIVES: Several factors in double filtration plasmapheresis (DFPP) were associated with triglyceride (TG) clearance rate. This study examines whether baseline whole blood viscosity was a predictor for efficient TG removal. METHODS: Adult subjects who receiving DFPP for hyperlipidemia in Taoyuan General Hospital from January 2015 to March 2018 were classified into efficient and inefficient TG removal according to TG removal rate ≥50% vs <50%. TG removal rate was defined as following formula: (pre-apheresis TG- post-apheresis TG)/pre-apheresis TG. Whole blood viscosity (WBV) was estimated by following equation: WBV = 0.12 × hematocrit +0.17 × (total protein -2.07). Univariate linear regression was used to assess the association between TG removal rate and WBV. Odds ratios (ORs) and 95% confidence interval (95%CI) for associations between variables and efficient TG removal were evaluated by logistic regression model to including univariate and multivariate adjustment. RESULTS: From a total of 66 subjects receiving DFPP, 37 subjects reached efficient TG removal. The difference in pre-apheresis TG levels, hematocrit, and WBV between efficient vs. inefficient TG removal groups was 4.1 vs 6.7 mmol/L; 43.1% vs 39.5%; and 6.0cP vs 5.cP (Ps <0.05). After multivariate adjustment, WBC was a significant predictor for efficient TG removal (ORs and 95% CI were 3.192 (1.300-7.838), P < 0.05). The correlation between WBV and extraction of TG was significant (r = -0.255, P = 0.039). CONCLUSION:Hyperviscosity reduced the efficiency of TG removal in those receiving DFPP.
Authors: Zbigniew M Szczepiorkowski; Jeffrey L Winters; Nicholas Bandarenko; Haewon C Kim; Michael L Linenberger; Marisa B Marques; Ravindra Sarode; Joseph Schwartz; Robert Weinstein; Beth H Shaz Journal: J Clin Apher Date: 2010 Impact factor: 2.821
Authors: Claudia Stefanutti; Ulrich Julius; Gerald F Watts; Mariko Harada-Shiba; Maria Cossu; Volker J Schettler; Giustina De Silvestro; Handrean Soran; Jeanine Roeters Van Lennep; Livia Pisciotta; Hans U Klör; Kurt Widhalm; Patrick M Moriarty Journal: J Clin Lipidol Date: 2017-04-25 Impact factor: 4.766
Authors: Vassilios G Athyros; Olga I Giouleme; Nikolaos L Nikolaidis; Themistoklis V Vasiliadis; Vassilios I Bouloukos; Athanasios G Kontopoulos; Nikolaos P Eugenidis Journal: J Clin Gastroenterol Date: 2002-04 Impact factor: 3.062
Authors: M Suzuki; S Yamane; T Matsugane; T Nobuto; N Azuma; T Nishide; M Shinomiya; K Saito; N Sasaki; Y Nosé Journal: Artif Organs Date: 1996-04 Impact factor: 3.094
Authors: Paul S Jellinger; Yehuda Handelsman; Paul D Rosenblit; Zachary T Bloomgarden; Vivian A Fonseca; Alan J Garber; George Grunberger; Chris K Guerin; David S H Bell; Jeffrey I Mechanick; Rachel Pessah-Pollack; Kathleen Wyne; Donald Smith; Eliot A Brinton; Sergio Fazio; Michael Davidson Journal: Endocr Pract Date: 2017-04 Impact factor: 3.443
Authors: Lars Berglund; John D Brunzell; Anne C Goldberg; Ira J Goldberg; Frank Sacks; Mohammad Hassan Murad; Anton F H Stalenhoef Journal: J Clin Endocrinol Metab Date: 2012-09 Impact factor: 5.958