Literature DB >> 30319855

Protective effects of Gastrodia elata Blume on acetaminophen-induced liver and kidney toxicity in rats.

Pu Reum Seok1, Jung Hoan Kim2, Hye Ri Kwon1, Jin Sun Heo1, Jong Ryeol Choi3, Jae-Ho Shin1.   

Abstract

An overdose of acetaminophen (AAP) causes hepatic and renal toxicity. This study examined the protective effects of Gastrodia elata Blume (GEB) on hepatic and renal injury induced by AAP. Rats were orally administered distilled water or GEB for 14 days and injected with AAP 1 h after the oral last administration; control rats were administered water without AAP injection. All rats were sacrificed 24 h after AAP injection. The GEB pretreatment group showed decreased necrosis and the expression of pro-inflammatory cytokines in the liver and kidney. TUNEL-positive cells and oxidative stress marker, such as malondialdehyde, were decreased. However, antioxidant enzymes, such as glutathione and superoxide dismutase, were increased. The expression of CYP2E1 and N-acetyl-beta-d-glucosaminidase was decreased in the GEB pretreatment group. This study shows that GEB prevents AAP-induced liver and kidney injury.

Entities:  

Keywords:  Acetaminophen; Gastrodia elata Blume; Kidney; Liver; Rats

Year:  2018        PMID： 30319855      PMCID： PMC6170282          DOI： 10.1007/s10068-018-0374-5

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  35 in total

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2.  A case of acetaminophen-induced acute tubulointerstitial nephritis in adult.

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3.  Glutamine protection in an experimental model of acetaminophen nephrotoxicity.

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4.  Protective effects of MESNA (2-mercaptoethane sulphonate) against acetaminophen-induced hepatorenal oxidative damage in mice.

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Journal:  J Appl Toxicol       Date:  2005 Jan-Feb       Impact factor: 3.446

Review 5.  Retrospect on the research of the cultivation of Gastrodia elata Bl, a rare traditional Chinese medicine.

Authors:  J Xu; S Guo
Journal:  Chin Med J (Engl)       Date:  2000-08       Impact factor: 2.628

Review 6.  Nonalcoholic fatty liver disease: Synopsis of current developments.

Authors:  C A Onyekwere; A O Ogbera; A A Samaila; B O Balogun; F B Abdulkareem
Journal:  Niger J Clin Pract       Date:  2015 Nov-Dec       Impact factor: 0.968

7.  Serum enzymes as indicators of chemically induced liver damage.

Authors:  R B Drotman; G T Lawhorn
Journal:  Drug Chem Toxicol       Date:  1978       Impact factor: 3.356

8.  Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death.

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Journal:  Phytother Res       Date:  2015-12-08       Impact factor: 5.878

9.  2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside exacerbates acetaminophen-induced hepatotoxicity by inducing hepatic expression of CYP2E1, CYP3A4 and CYP1A2.

Authors:  Shangfu Xu; Jie Liu; Jingshan Shi; Zhengtao Wang; Lili Ji
Journal:  Sci Rep       Date:  2017-11-28       Impact factor: 4.379

10.  In vitro and in vivo antioxidative and hepatoprotective activity of aqueous extract of Cortex Dictamni.

Authors:  Lin Li; Yun-Feng Zhou; Yan-Lin Li; Li-Li Wang; Hiderori Arai; Yang Xu
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  2 in total

1.  Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways.

Authors:  Chia-Chih Liao; Huang-Ping Yu; An-Hsun Chou; Hung-Chen Lee; Li-Min Hu; Fu-Chao Liu
Journal:  Inflammation       Date:  2022-04-26       Impact factor: 4.092

2.  Optimal Extraction Study of Gastrodin-Type Components from Gastrodia Elata Tubers by Response Surface Design with Integrated Phytochemical and Bioactivity Evaluation.

Authors:  Minhui Hu; Hui Yan; Yuanyuan Fu; Yulan Jiang; Weifeng Yao; Sheng Yu; Li Zhang; Qinan Wu; Anwei Ding; Mingqiu Shan
Journal:  Molecules       Date:  2019-02-02       Impact factor: 4.411
  2 in total

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