| Literature DB >> 30319854 |
Eun Hye Han1, Mi Kyung Lim1, Sang Ho Lee1, Hyoung Ja Kim2, Dahyun Hwang3,4.
Abstract
In this study, synergistic hypoudpricemic activities between ethanol extract of Aster glehni (AG) and vitamin B6 were investigated in vitro and in vivo. Xanthine oxidase inhibitory activities in the different parts, leaf, stem, and flower, during spring and autumn were compared. In addition, to improve hypouricemic activity, two chemicals (AG extract and vitamins) were mixed and measured inhibitory activity of xanthine oxidase. As a result, autumn leaf AG extracts showed the most effective xanthine oxidase inhibitory activity and we named autumn leaf AG extracts as AG-D006. In synergistic study, AG-D006 with vitamin B6 showed significantly increased inhibitory activity on xanthine oxidase. AG-D006 with vitamin B6 also showed significantly reduced uric acid level in hyperuricemic rats in vivo. In conclusion, AG-D006 with vitamin B6 might be used functional foods in reducing serum uric acid level in gout.Entities:
Keywords: Aster glehni; Hyperuricemic; Synergism; Vitamin B6; Xanthine oxidase
Year: 2018 PMID： 30319854 PMCID： PMC6170285 DOI： 10.1007/s10068-018-0394-1
Source DB: PubMed Journal: Food Sci Biotechnol ISSN： 1226-7708 Impact factor: 2.391