Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.

Literature DB >> 3031677

Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.

Abstract

More than 70% of wild-type Rous sarcoma virus p60v-src was found to be associated with a cellular structure resistant to nonionic detergent extraction that consists primarily of cytoskeletal proteins. On the other hand, nontransforming src proteins, including cellular p60c-src, nonmyristoylated forms, and those inactive in protein kinase, were found in the fraction solubilized by the detergent extraction. p60c-src was detergent-soluble even in transformed cells, suggesting that the association of p60v-src is not a result of cell transformation. Analyses with a variety of Rous sarcoma virus mutants showed a good correlation between the degree of association with the detergent-resistant structure and the extent of cell transformation caused by mutant src proteins, suggesting that this association may be significant for the process of cell transformation by Rous sarcoma virus.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1987 PMID： 3031677 PMCID： PMC304640 DOI： 10.1073/pnas.84.8.2312

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

48 in total

1. Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

Authors: J A Cooper; T Hunter
Journal: Mol Cell Biol Date: 1981-02 Impact factor: 4.272

2. Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.

Authors: R A Feldman; L H Wang; H Hanafusa; P C Balduzzi
Journal: J Virol Date: 1982-04 Impact factor: 5.103

3. Transformation of rat cells by fusion-infection with Rous sarcoma virus.

Authors: S Kawai
Journal: J Virol Date: 1980-06 Impact factor: 5.103

4. The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins.

Authors: A Ben-Ze'ev; A Duerr; F Solomon; S Penman
Journal: Cell Date: 1979-08 Impact factor: 41.582

5. Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.

Authors: S Kawai; M Yoshida; K Segawa; H Sugiyama; R Ishizaki; K Toyoshima
Journal: Proc Natl Acad Sci U S A Date: 1980-10 Impact factor: 11.205

6. Association of the src gene product of Rous sarcoma virus with cytoskeletal structures of chicken embryo fibroblasts.

Authors: J G Burr; G Dreyfuss; S Penman; J M Buchanan
Journal: Proc Natl Acad Sci U S A Date: 1980-06 Impact factor: 11.205

7. Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicity.

Authors: J G Krueger; E A Garber; A R Goldberg; H Hanafusa
Journal: Cell Date: 1982-04 Impact factor: 41.582

8. Transformation by avian sarcoma viruses leads to phosphorylation of multiple cellular proteins on tyrosine residues.

Authors: K Beemon; T Ryden; E A McNelly
Journal: J Virol Date: 1982-05 Impact factor: 5.103

9. Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells.

Authors: M Cervera; G Dreyfuss; S Penman
Journal: Cell Date: 1981-01 Impact factor: 41.582

10. Filament organization revealed in platinum replicas of freeze-dried cytoskeletons.

Authors: J E Heuser; M W Kirschner
Journal: J Cell Biol Date: 1980-07 Impact factor: 10.539

55 in total

1. Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

Authors: Q Yang; N K Tonks
Journal: Proc Natl Acad Sci U S A Date: 1991-07-15 Impact factor: 11.205

2. Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

Authors: R R Roussel; S R Brodeur; D Shalloway; A P Laudano
Journal: Proc Natl Acad Sci U S A Date: 1991-12-01 Impact factor: 11.205

3. A glycoprotein in the plasma membrane matrix as a major potential substrate of p60v-src.

Authors: M Hamaguchi; M Matsuda; H Hanafusa
Journal: Mol Cell Biol Date: 1990-02 Impact factor: 4.272

4. The integrity of the SH3 binding motif of AFAP-110 is required to facilitate tyrosine phosphorylation by, and stable complex formation with, Src.

Authors: A C Guappone; D C Flynn
Journal: Mol Cell Biochem Date: 1997-10 Impact factor: 3.396

8. Reovirus polypeptide sigma 3 and N-terminal myristoylation of polypeptide mu 1 are required for site-specific cleavage to mu 1C in transfected cells.

Authors: L Tillotson; A J Shatkin
Journal: J Virol Date: 1992-04 Impact factor: 5.103

9. Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets.

Authors: E A Clark; J S Brugge
Journal: Mol Cell Biol Date: 1993-03 Impact factor: 4.272

10. Expression of p60v-src in Saccharomyces cerevisiae results in elevation of p34CDC28 kinase activity and release of the dependence of DNA replication on mitosis.

Authors: F Boschelli
Journal: Mol Cell Biol Date: 1993-08 Impact factor: 4.272