| Literature DB >> 30316681 |
Liis Sabre1, Jeffrey T Guptill2, Melissa Russo2, Vern C Juel2, Janice M Massey2, James F Howard3, Lisa D Hobson-Webb2, Anna Rostedt Punga4.
Abstract
Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.Entities:
Keywords: Biomarker; MuSK; Muscle-specific tyrosine kinase; Myasthenia gravis; microRNA
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Year: 2018 PMID: 30316681 PMCID: PMC6240475 DOI: 10.1016/j.jneuroim.2018.10.003
Source DB: PubMed Journal: J Neuroimmunol ISSN: 0165-5728 Impact factor: 3.478