Literature DB >> 30316679

Effect of dexamethasone on seizures and inflammatory profile induced by Kindling Seizure Model.

Edson Fernando Müller Guzzo1, Karina Rodrigues Lima2, Carmen Regla Vargas3, Adriana Simon Coitinho4.   

Abstract

The objective of this study was to evaluate the effect of dexamethasone, on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by pentylenetetrazole (20 mg/kg) in alternated days for 15 days of treatment. The animals were divided into five groups: control group given saline, a group treated with diazepam (2 mg/kg) and groups treated with dexamethasone (1, 2 and 4 mg/kg). Open field test was conducted. The treatment with dexamethasone decreased the severity of seizures, also decreased TNF-alpha and Interleukin 1 beta levels in the hippocampus and TNF-alpha level in the serum.
Copyright © 2018 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Dexamethasone; Epilepsy; Inflammation

Mesh：

Substances：

Year:  2018        PMID： 30316679     DOI： 10.1016/j.jneuroim.2018.10.005

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  4 in total

1.  Gamma-Decanolactone Alters the Expression of GluN2B, A1 Receptors, and COX-2 and Reduces DNA Damage in the PTZ-Induced Seizure Model After Subchronic Treatment in Mice.

Authors:  Fernanda Marcelia Dos Santos; Pricila Fernandes Pflüger; Leticia Lazzarotto; Mariana Uczay; Wesley Roberto de Aguida; Lisiane Santos da Silva; Fernanda Brião Menezes Boaretto; Jayne Torres de Sousa; Jaqueline Nascimento Picada; Iraci Lucena da Silva Torres; Patrícia Pereira
Journal:  Neurochem Res       Date:  2021-05-21       Impact factor: 3.996

2.  Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Nrf2 Signaling Pathway.

Authors:  Arooj Mohsin Alvi; Lina Tariq Al Kury; Abdullah Alattar; Ikram Ullah; Asmaa Jan Muhammad; Reem Alshaman; Fawad Ali Shah; Arif Ullah Khan; Jinxing Feng; Shupeng Li
Journal:  Oxid Med Cell Longev       Date:  2021-08-11       Impact factor: 6.543

3.  Parameters of Oxidative Stress and Behavior in Animals Treated with Dexametasone and Submitted to Pentylenetetrazol Kindling.

Authors:  Edson Fernando Muller Guzzo; Gabriel de Lima Rosa; Rafael Padilha Bremm; Caroline Paula Meska; Carmen Regla Vargas; Adriana Simon Coitinho
Journal:  J Epilepsy Res       Date:  2021-12-31

4.  1,3,4, Oxadiazole Compound A3 Provides Robust Protection Against PTZ-Induced Neuroinflammation and Oxidative Stress by Regulating Nrf2-Pathway.

Authors:  Arooj Mohsin Alvi; Fawad Ali Shah; Asmaa Jan Muhammad; Jinxing Feng; Shupeng Li
Journal:  J Inflamm Res       Date:  2021-12-29
  4 in total

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