Literature DB >> 3031664

Two promoters, one inducible and one constitutive, control transcription of the Streptomyces lividans galactose operon.

J A Fornwald, F J Schmidt, C W Adams, M Rosenberg, M E Brawner.   

Abstract

Galactose utilization in Streptomyces lividans was shown to be controlled by an operon that is induced in the presence of galactose and repressed by glucose. Two promoters, galP1 and galP2, which direct transcription of two distinct polycistronic transcripts, have been identified. galP1 is located immediately upstream of the operon and is induced in the presence of galactose. This promoter directs transcription of the galT, galE, and galK genes. The second promoter, galP2, is located within the operon just upstream of the galE gene. This promoter is responsible for constitutive transcription of the galE and galK genes. Comparison of the S. lividans gal operon to the Escherichia coli gal operon indicates the presence of a constitutive promoter positioned upstream of galE in both operons. We suggest that coupling the operon's constitutive promoter to the galE gene fulfills a physiological requirement for constitutive UDPgalactose 4-epimerase expression in Streptomyces.

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Year:  1987        PMID： 3031664      PMCID： PMC304602          DOI： 10.1073/pnas.84.8.2130

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  25 in total

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Authors:  G Barry; C L Squires; C Squires
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

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Authors:  K McKenney; H Shimatake; D Court; U Schmeissner; C Brady; M Rosenberg
Journal:  Gene Amplif Anal       Date:  1981

6.  The nucleotide sequence of the initiation and termination sites for ribosomal RNA transcription in X. laevis.

Authors:  B Sollner-Webb; R H Reeder
Journal:  Cell       Date:  1979-10       Impact factor: 41.582

7.  Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA.

Authors:  S N Cohen; A C Chang; L Hsu
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

8.  Characterization of temperate actinophage phi C31 isolated from Streptomyces coelicolor A3(2).

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Journal:  J Virol       Date:  1972-02       Impact factor: 5.103

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Authors:  D A Hopwood; H M Wright
Journal:  Mol Gen Genet       Date:  1978-07-04

10.  Cyclic adenosine monophosphate in bacteria.

Authors:  I Pastan; R Perlman
Journal:  Science       Date:  1970-07-24       Impact factor: 47.728
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  29 in total

Review 1.  Compilation and analysis of DNA sequences associated with apparent streptomycete promoters.

Authors:  W R Strohl
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

2.  Cloning, sequencing, and regulation of expression of an extracellular esterase gene from the plant pathogen Streptomyces scabies.

Authors:  G Raymer; J M Willard; J L Schottel
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

Review 3.  Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

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Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

4.  Sequence and transcriptional analysis of the Streptomyces glaucescens tcmAR tetracenomycin C resistance and repressor gene loci.

Authors:  P G Guilfoile; C R Hutchinson
Journal:  J Bacteriol       Date:  1992-06       Impact factor: 3.490

5.  Transcriptional regulation of the Streptococcus mutans gal operon by the GalR repressor.

Authors:  D Ajdić; J J Ferretti
Journal:  J Bacteriol       Date:  1998-11       Impact factor: 3.490

6.  A cloned regulatory gene of Streptomyces lividans can suppress the pigment deficiency phenotype of different developmental mutants.

Authors:  D Stein; S N Cohen
Journal:  J Bacteriol       Date:  1989-04       Impact factor: 3.490

7.  Computer assisted identification and classification of streptomycete promoters.

Authors:  W R Bourn; B Babb
Journal:  Nucleic Acids Res       Date:  1995-09-25       Impact factor: 16.971

8.  Identification of a complex operator for galP1, the glucose-sensitive, galactose-dependent promoter of the Streptomyces galactose operon.

Authors:  S G Mattern; M E Brawner; J Westpheling
Journal:  J Bacteriol       Date:  1993-03       Impact factor: 3.490

9.  Minimal requirements of the Streptomyces lividans 66 oriC region and its transcriptional and translational activities.

Authors:  J Zakrzewska-Czerwińska; J Majka; H Schrempf
Journal:  J Bacteriol       Date:  1995-08       Impact factor: 3.490

10.  Direct repeat sequences are implicated in the regulation of two Streptomyces chitinase promoters that are subject to carbon catabolite control.

Authors:  I Delic; P Robbins; J Westpheling
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205
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