Mohammadali Beheshti1, Karl Magtibay1, Stéphane Massé1, Andreu Porta-Sanchez2, Shouvik Haldar3, Abhishek Bhaskaran1, Sachin Nayyar1, Benedict Glover4, D Curtis Deno5, Edward J Vigmond6, Kumaraswamy Nanthakumar7. 1. University Health Network, Toronto General Hospital, Toronto, ON, Canada. 2. Hospital Universitario Quirónsalud Madrid and Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain. 3. Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom. 4. Department of Medicine, Queens University, ON, Canada. 5. Abbott Laboratories, St. Paul, MN, USA. 6. University of Bordeaux, IMB, UMR 5251, F-33400 Talence, France; IHU Liryc, Electrophysiology and Heart Modeling Institute, Fondation Bordeaux Université, F-33600 Pessac, Bordeaux, France. Electronic address: edward.vigmond@u-bordeaux.fr. 7. University Health Network, Toronto General Hospital, Toronto, ON, Canada. Electronic address: kumar.nanthakumar@uhn.ca.
Abstract
BACKGROUND: Local bipolar electrogram (EGM) peak-to-peak voltage (Vpp) is currently used to characterise mapped myocardial substrate. However, how interelectrode distance and angle of wavefront incidence affect bipolar, Vpp values, in the current era of multi-electrode mapping is unknown. OBJECTIVES: To elucidate the effects of tissue and electrode geometry on bipolar Vpp measurements, when mapping healthy versus diseased atrial regions. METHODS: A bidomain model of human atrial tissue was used to quantify the influence on Vpp values of various electrode configurations in healthy tissue, and tissue containing an unexcitable region. The orientation angle and interelectrode spacing of a surface bipole, and thickness and depth of the unexcitable core were serially varied. Results were validated with data obtained from isolated porcine hearts. RESULTS: In healthy tissue, bipolar Vpp values increased with increasing interelectrode spacing and plateaued beyond a spacing of approximately 4 mm. The bipolar Vpp values in healthy tissue were relatively less sensitive to wavefront orientation angle with large interelectrode spacing. In diseased tissue, on the contrary, with increasing interelectrode spacing, bipolar Vpp values increased linearly without a plateau and were more sensitive to orientation angle. The bipolar Vpp values decreased with increasing thickness of the scar, with larger relative decrease in small bipoles than larger ones. Bipolar Vpp values increased with a progressively intramural location of fixed-size scar and became less distinguishable from healthy tissue especially for smaller interelectrode spacings. CONCLUSIONS: The scalable relationship established for interelectrode distances favour an electric-field-based assessment as opposed to traditional Vpp values as a tool for physiologically relevant measurement for mapping catheters with interelectrode spacing up to 4 mm. This will allow for universal assessment of myocardial health across catheters with varied spacing.
BACKGROUND: Local bipolar electrogram (EGM) peak-to-peak voltage (Vpp) is currently used to characterise mapped myocardial substrate. However, how interelectrode distance and angle of wavefront incidence affect bipolar, Vpp values, in the current era of multi-electrode mapping is unknown. OBJECTIVES: To elucidate the effects of tissue and electrode geometry on bipolar Vpp measurements, when mapping healthy versus diseased atrial regions. METHODS: A bidomain model of human atrial tissue was used to quantify the influence on Vpp values of various electrode configurations in healthy tissue, and tissue containing an unexcitable region. The orientation angle and interelectrode spacing of a surface bipole, and thickness and depth of the unexcitable core were serially varied. Results were validated with data obtained from isolated porcine hearts. RESULTS: In healthy tissue, bipolar Vpp values increased with increasing interelectrode spacing and plateaued beyond a spacing of approximately 4 mm. The bipolar Vpp values in healthy tissue were relatively less sensitive to wavefront orientation angle with large interelectrode spacing. In diseased tissue, on the contrary, with increasing interelectrode spacing, bipolar Vpp values increased linearly without a plateau and were more sensitive to orientation angle. The bipolar Vpp values decreased with increasing thickness of the scar, with larger relative decrease in small bipoles than larger ones. Bipolar Vpp values increased with a progressively intramural location of fixed-size scar and became less distinguishable from healthy tissue especially for smaller interelectrode spacings. CONCLUSIONS: The scalable relationship established for interelectrode distances favour an electric-field-based assessment as opposed to traditional Vpp values as a tool for physiologically relevant measurement for mapping catheters with interelectrode spacing up to 4 mm. This will allow for universal assessment of myocardial health across catheters with varied spacing.
Authors: Edward J Ciaccio; Elaine Y Wan; Deepak S Saluja; U Rajendra Acharya; Nicholas S Peters; Hasan Garan Journal: Comput Methods Programs Biomed Date: 2019-06-15 Impact factor: 5.428
Authors: Deborah Nairn; Heiko Lehrmann; Björn Müller-Edenborn; Steffen Schuler; Thomas Arentz; Olaf Dössel; Amir Jadidi; Axel Loewe Journal: Front Physiol Date: 2020-11-26 Impact factor: 4.566