Literature DB >> 30315919

Quasispecies dynamics and clinical significance of hepatitis C virus (HCV) antiviral resistance.

Celia Perales1.   

Abstract

Hepatitis C virus (HCV) follows quasispecies dynamics in infected hosts and this influences its biology, how the virus diversifies into several genotypes and many subtypes, and how viral populations respond to antiviral therapies. Despite current antiviral combinations being able to cure a great percentage of HCV-infected patients, the presence of resistance-associated substitutions (RASs) diminishes the success of antiviral therapies, which is a main concern in the re-treatment of patients treated with direct-acting antiviral agents. Current methodologies such as ultra deep sequencing are ideal tools to obtain a detailed representation of the mutant spectrum composition circulating in infected patients. Such knowledge should allow optimisation of rescue treatments. A new mechanism of antiviral resistance not based on the selection of RASs but on high viral fitness is discussed.
Copyright © 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

Entities:  

Keywords:  Direct-acting antiviral; Drug resistance; HCV; Hepatitis C virus; Viral quasispecies

Mesh：

Substances：

Year:  2018        PMID： 30315919     DOI： 10.1016/j.ijantimicag.2018.10.005

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  9 in total

1.  Broad and Dynamic Diversification of Infectious Hepatitis C Virus in a Cell Culture Environment.

Authors:  Isabel Gallego; María Eugenia Soria; Carlos García-Crespo; Qian Chen; Patricia Martínez-Barragán; Soumaya Khalfaoui; Brenda Martínez-González; Irene Sanchez-Martin; Inés Palacios-Blanco; Ana Isabel de Ávila; Damir García-Cehic; Juan Ignacio Esteban; Jordi Gómez; Carlos Briones; Josep Gregori; Josep Quer; Celia Perales; Esteban Domingo
Journal:  J Virol       Date:  2020-02-28       Impact factor: 5.103

2.  SARS-CoV-2 Mutant Spectra at Different Depth Levels Reveal an Overwhelming Abundance of Low Frequency Mutations.

Authors:  Brenda Martínez-González; María Eugenia Soria; Lucía Vázquez-Sirvent; Cristina Ferrer-Orta; Rebeca Lobo-Vega; Pablo Mínguez; Lorena de la Fuente; Carlos Llorens; Beatriz Soriano; Ricardo Ramos-Ruíz; Marta Cortón; Rosario López-Rodríguez; Carlos García-Crespo; Pilar Somovilla; Antoni Durán-Pastor; Isabel Gallego; Ana Isabel de Ávila; Soledad Delgado; Federico Morán; Cecilio López-Galíndez; Jordi Gómez; Luis Enjuanes; Llanos Salar-Vidal; Mario Esteban-Muñoz; Jaime Esteban; Ricardo Fernández-Roblas; Ignacio Gadea; Carmen Ayuso; Javier Ruíz-Hornillos; Nuria Verdaguer; Esteban Domingo; Celia Perales
Journal:  Pathogens       Date:  2022-06-08

3.  Prevalence and Factors Related to Natural Resistance-Associated Substitutions to Direct-Acting Antivirals in Patients with Genotype 1 Hepatitis C Virus Infection.

Authors:  Isabella Esposito; Sebastián Marciano; Leila Haddad; Omar Galdame; Alejandra Franco; Adrián Gadano; Diego Flichman; Julieta Trinks
Journal:  Viruses       Date:  2018-12-21       Impact factor: 5.048

Review 4.  Population Disequilibrium as Promoter of Adaptive Explorations in Hepatitis C Virus.

Authors:  Carlos García-Crespo; Isabel Gallego; María Eugenia Soria; Ana Isabel de Ávila; Brenda Martínez-González; Lucía Vázquez-Sirvent; Rebeca Lobo-Vega; Elena Moreno; Jordi Gómez; Carlos Briones; Josep Gregori; Josep Quer; Esteban Domingo; Celia Perales
Journal:  Viruses       Date:  2021-04-03       Impact factor: 5.048

5.  Study of Quasispecies Complexity and Liver Damage Progression after Liver Transplantation in Hepatitis C Virus Infected Patients.

Authors:  Meritxell Llorens-Revull; Josep Gregori; Cristina Dopazo; Francisco Rodriguez-Frías; Damir Garcia-Cehic; Maria Eugenia Soria; Qian Chen; Ariadna Rando; Celia Perales; Juan Ignacio Esteban; Josep Quer; Itxarone Bilbao
Journal:  Genes (Basel)       Date:  2021-10-28       Impact factor: 4.096

6.  A Two-Level, Intramutant Spectrum Haplotype Profile of Hepatitis C Virus Revealed by Self-Organized Maps.

Authors:  Soledad Delgado; Celia Perales; Carlos García-Crespo; María Eugenia Soria; Isabel Gallego; Ana Isabel de Ávila; Brenda Martínez-González; Lucía Vázquez-Sirvent; Cecilio López-Galíndez; Federico Morán; Esteban Domingo
Journal:  Microbiol Spectr       Date:  2021-11-10

7.  Efficacy decrease of antiviral agents when administered to ongoing hepatitis C virus infections in cell culture.

Authors:  Carlos García-Crespo; Lucía Vázquez-Sirvent; Pilar Somovilla; María Eugenia Soria; Isabel Gallego; Ana Isabel de Ávila; Brenda Martínez-González; Antoni Durán-Pastor; Esteban Domingo; Celia Perales
Journal:  Front Microbiol       Date:  2022-08-03       Impact factor: 6.064

8.  Late Relapse and Reinfection in HCV Patients Treated with Direct-Acting Antiviral (DAA) Drugs.

Authors:  Claudia Minosse; Cesare E M Gruber; Martina Rueca; Chiara Taibi; Mauro Zaccarelli; Elisabetta Grilli; Marzia Montalbano; Maria R Capobianchi; Andrea Antinori; Gianpiero D'Offizi; Fiona McPhee; Anna Rosa Garbuglia
Journal:  Viruses       Date:  2021-06-16       Impact factor: 5.048

9.  Viral quasispecies.

Authors:  Esteban Domingo; Celia Perales
Journal:  PLoS Genet       Date:  2019-10-17       Impact factor: 5.917
  9 in total

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