Meri Sieviläinen1, Rabeia Almahmoudi1, Ahmed Al-Samadi1, Tuula Salo1,2,3, Matti Pirinen4,5,6, Alhadi Almangush1,7,8. 1. Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland. 2. Medical Research Centre, Oulu University Hospital, Oulu, Finland. 3. Department of Diagnostics and Oral Medicine, Medical Faculty, Research Group of Cancer Research and Translational Medicine, University of Oulu, Oulu, Finland. 4. Institute for Molecular Medicine Finland FIMM, Helsinki Institute of Life Science HiLIFE, University of Helsinki, Helsinki, Finland. 5. Department of Public Health, University of Helsinki, Helsinki, Finland. 6. Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. 7. Department of Pathology, University of Helsinki, Helsinki, Finland. 8. Institute of Dentistry, University of Misurata, Misurata, Libya.
Abstract
BACKGROUND: Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC. MATERIALS: A systematic search was conducted in Ovid Medline, Scopus and Cochrane libraries, and all studies that evaluated the prognostic significance of immune checkpoints in OSCC were systematically retrieved. RESULTS: Twelve immune checkpoints/modulators were studied for their prognostic values in OSCC patients between 1985 and 2017. Seven immune checkpoints (FKBP51, B7-H4, B7-H6, ALHD1, PD-L1, B7-H3 and IDO1) were reported to be associated with poor patients' survival in at least one study, and five (CTLA-4, TLT-2, VISTA, PD-L2 and PD-1) did not have a significant prognostic value. PD-L1 results were controversial as it was reported to be associated with both better and worse patients' survival. CONCLUSIONS: Even though immune checkpoint markers had high expectation for OSCC prognostication, our systematic review revealed that the majority of them had been studied only once. The other molecules, which had been studied more than once, had controversial findings, except B7-H3.
BACKGROUND: Despite the importance of immune checkpoints in immunotherapy, the prognostic value of these molecules remains controversial in oral squamous cell carcinoma (OSCC). We performed a systematic review to investigate the prognostic significance of the immune checkpoints in OSCC. MATERIALS: A systematic search was conducted in Ovid Medline, Scopus and Cochrane libraries, and all studies that evaluated the prognostic significance of immune checkpoints in OSCC were systematically retrieved. RESULTS: Twelve immune checkpoints/modulators were studied for their prognostic values in OSCC patients between 1985 and 2017. Seven immune checkpoints (FKBP51, B7-H4, B7-H6, ALHD1, PD-L1, B7-H3 and IDO1) were reported to be associated with poor patients' survival in at least one study, and five (CTLA-4, TLT-2, VISTA, PD-L2 and PD-1) did not have a significant prognostic value. PD-L1 results were controversial as it was reported to be associated with both better and worse patients' survival. CONCLUSIONS: Even though immune checkpoint markers had high expectation for OSCC prognostication, our systematic review revealed that the majority of them had been studied only once. The other molecules, which had been studied more than once, had controversial findings, except B7-H3.
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Authors: Aini Hyytiäinen; Rabeia Almahmoudi; Meri Sieviläinen; Anna Maria Wirsing; Priscila Rodrigues; Inger-Heidi Bjerkli; Pirjo Åström; Sanna Toppila-Salmi; Timo Paavonen; Ricardo D Coletta; Elin Hadler-Olsen; Tuula Salo; Ahmed Al-Samadi Journal: Head Neck Pathol Date: 2020-09-21