Literature DB >> 30315460

Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice.

Dorien Broekaert1,2, Sarah-Maria Fendt3.   

Abstract

Metabolic alterations are a hallmark of cancer. While determining metabolic changes in vitro has delivered valuable insight into the metabolism of cancer cells, it emerges that determining the in vivo metabolism adds an additional layer of information. Here, we therefore describe how to measure the in vivo metabolism of cancer tissue using 13C glucose infusions in mice.

Entities:  

Keywords:  13C glucose infusions; 13C tracer analysis; Cancer metabolism; In vivo metabolism; Metabolomics

Mesh：

Substances：

Year:  2019        PMID： 30315460     DOI： 10.1007/978-1-4939-8769-6_5

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

Review 1.  Stable isotope tracing to assess tumor metabolism in vivo.

Authors:  Brandon Faubert; Alpaslan Tasdogan; Sean J Morrison; Thomas P Mathews; Ralph J DeBerardinis
Journal:  Nat Protoc       Date:  2021-09-17       Impact factor: 17.021

2.  In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition.

Authors:  Gianmarco Rinaldi; Erica Pranzini; Joke Van Elsen; Dorien Broekaert; Cornelius M Funk; Mélanie Planque; Ginevra Doglioni; Patricia Altea-Manzano; Matteo Rossi; Vincent Geldhof; Shao Thing Teoh; Christina Ross; Kent W Hunter; Sophia Y Lunt; Thomas G P Grünewald; Sarah-Maria Fendt
Journal:  Mol Cell       Date:  2020-12-18       Impact factor: 19.328

3.  Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.

Authors:  Nick van Gastel; Jessica B Spinelli; Marcia C Haigis; David T Scadden
Journal:  Bio Protoc       Date:  2021-10-05

Review 4.  Existing and Emerging Metabolomic Tools for ALS Research.

Authors:  Christine Germeys; Tijs Vandoorne; Valérie Bercier; Ludo Van Den Bosch
Journal:  Genes (Basel)       Date:  2019-12-05       Impact factor: 4.096

5.  Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics.

Authors:  Holden C Williams; Margaret A Piron; Grant K Nation; Adeline E Walsh; Lyndsay E A Young; Ramon C Sun; Lance A Johnson
Journal:  Metabolites       Date:  2020-12-08

6.  Altered propionate metabolism contributes to tumour progression and aggressiveness.

Authors:  Ana P Gomes; Didem Ilter; Vivien Low; Stanislav Drapela; Tanya Schild; Edouard Mullarky; Julie Han; Ilaria Elia; Dorien Broekaert; Adam Rosenzweig; Michal Nagiec; Joana B Nunes; Bethany E Schaffer; Anders P Mutvei; John M Asara; Lewis C Cantley; Sarah-Maria Fendt; John Blenis
Journal:  Nat Metab       Date:  2022-03-31
  6 in total

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