| Literature DB >> 30314839 |
Andrea Olschewski1, Eva M Berghausen2, Christina A Eichstaedt3, Bernd K Fleischmann4, Ekkehard Grünig5, Gabriele Grünig6, Georg Hansmann7, Lars Harbaum8, Jan K Hennigs9, Danny Jonigk10, Wolfgang M Kuebler11, Grazyna Kwapiszewska12, Soni S Pullamsetti13, Elvira Stacher14, Norbert Weissmann15, Daniela Wenzel4, Ralph T Schermuly15.
Abstract
The European guidelines, which focus on clinical aspects of pulmonary hypertension (PH), provide only minimal information about the pathophysiological concepts of PH. Here, we review this topic in greater detail, focusing on specific aspects in the pathobiology, pathology and genetics, which include mechanisms of vascular inflammation, the role of transcription factors, ion channels/ion channel diseases, hypoxic pulmonary vasoconstriction, genetics/epigenetics, metabolic dysfunction, and the potential future role of histopathology of PH in the modern era of PH therapy. In addition to new insights in the pathobiology of this disease, this working group of the Cologne Consensus Conference also highlights novel concepts and potential new therapeutic targets to further improve the treatment options in PAH.Entities:
Keywords: And the potential future role of histopathology; Genetics/epigenetics; Hypoxic pulmonary vasoconstriction; Inflammation; Ion channels/ion channel diseases; Metabolic dysfunction; Pulmonary hypertension; Transcription factors
Mesh：
Substances：
Year: 2018 PMID： 30314839 DOI： 10.1016/j.ijcard.2018.09.070
Source DB: PubMed Journal: Int J Cardiol ISSN： 0167-5273 Impact factor: 4.164