Effects of platelet-rich plasma and platelet-poor plasma on human dermal fibroblasts.

Platelet-rich plasma is an autologous and safe blood product containing a high concentration of platelets and leucocytes. Platelets, growth factors, leucocytes and plasma are fundamental fibroblast proliferation agents. Leucocytes' plasticity, reparative qualities, cross-talk between cells and capacity to orchestrate diverse outcomes are receiving considerable research attention. Fibroblasts are able to migrate and proliferate into the tissue surrounding a wound and subsequently deposit granulation tissue, which minimises scarring. Fibroblasts also have anti-ageing benefits. Elucidation of the role of leucocytes in tissue repair has led to a new approach to tissue regeneration and the formation of a new therapeutic modality, namely immuno-regenerative medicine.