| Literature DB >> 30312931 |
Mateusz D Tomczyk1, Krzysztof Z Walczak2.
Abstract
In this review, we describe a detailed investigation about the structural variations and relative activity of 1,8-naphthalimide based intercalators and anticancer agents. The 1,8-naphthalimides binds to the DNA via intercalation, and exert their antitumor activities through Topoisomerase I/II inhibition, photoinduced DNA damage or related mechanism. Here, our discussion focused on works published over the last ten years (2007-2017) related to therapeutic applications, in the order of cancer treatment followed by other properties of 1,8-naphthalimides. In preparing for this review, we considered that several seminal reviews have appeared over the last fifteen years and focused on closely related subjects, however, none of them is exhaustive.Entities:
Keywords: 1,8-Naphthalimides; Amonafide; Anticancer agents; DNA intercalators; Mitonafide
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Year: 2018 PMID： 30312931 DOI： 10.1016/j.ejmech.2018.09.055
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514