Frank Qian1, Shengfeng Wang2,3, Jonathan Mitchell4, Lesley McGuffog5, Daniel Barrowdale5, Goska Leslie5, Jan C Oosterwijk6, Wendy K Chung7, D Gareth Evans8, Christoph Engel9,10, Karin Kast11,12, Cora M Aalfs13,14,15, Muriel A Adank16, Julian Adlard17,12, Bjarni A Agnarsson18,19, Kristiina Aittomäki20, Elisa Alducci21,12, Irene L Andrulis22,23, Banu K Arun24, Margreet G E M Ausems25, Jacopo Azzollini26, Emmanuelle Barouk-Simonet27,28, Julian Barwell29,30, Muriel Belotti31, Javier Benitez32, Andreas Berger33, Ake Borg34,35, Angela R Bradbury36, Joan Brunet31,37,38, Saundra S Buys39, Trinidad Caldes40, Maria A Caligo41, Ian Campbell42,43, Sandrine M Caputo29,31, Jocelyne Chiquette44, Kathleen B M Claes45, J Margriet Collée46, Fergus J Couch47, Isabelle Coupier48, Mary B Daly49, Rosemarie Davidson50, Orland Diez51, Susan M Domchek36, Alan Donaldson52, Cecilia M Dorfling53,54, Ros Eeles55, Lidia Feliubadaló56, Lenka Foretova57,58, Jeffrey Fowler59, Eitan Friedman60,61, Debra Frost5, Patricia A Ganz32, Judy Garber34, Vanesa Garcia-Barberan40, Gord Glendon22, Andrew K Godwin28, Encarna B Gómez Garcia12, Jacek Gronwald12, Eric Hahnen62, Ute Hamann, Alex Henderson35, Carolyn B Hendricks54, John L Hopper56, Peter J Hulick14,15, Evgeny N Imyanitov51, Claudine Isaacs63, Louise Izatt64, Ángel Izquierdo30, Anna Jakubowska12, Katarzyna Kaczmarek12, Eunyoung Kang65, Beth Y Karlan66, Carolien M Kets67, Sung-Won Kim68, Zisun Kim69, Ava Kwong70,71,72, Yael Laitman60, Christine Lasset73, Min Hyuk Lee74, Jong Won Lee75, Jihyoun Lee12,66,74, Jenny Lester12, Fabienne Lesueur76,77,78,79, Jennifer T Loud80, Jan Lubinski12, Noura Mebirouk76,77,78,79, Hanne E J Meijers-Heijboer81, Alfons Meindl82,83, Austin Miller82, Marco Montagna84, Thea M Mooij85, Patrick J Morrison86, Emmanuelle Mouret-Fourme31, Katherine L Nathanson, Susan L Neuhausen87, Heli Nevanlinna88, Dieter Niederacher89, Finn C Nielsen90, Robert L Nussbaum91, Kenneth Offit92,93, Edith Olah94, Kai-Ren Ong95, Laura Ottini96, Sue K Park97, Paolo Peterlongo98, Georg Pfeiler99, Catherine M Phelan100, Bruce Poppe45, Nisha Pradhan92, Paolo Radice101, Susan J Ramus102,103, Johanna Rantala104, Mark Robson93, Gustavo C Rodriguez105, Rita K Schmutzler62, Christina G Hutten Selkirk14, Payal D Shah36, Jacques Simard106, Christian F Singer107, Johanna Sokolowska108, Dominique Stoppa-Lyonnet109,110, Christian Sutter111, Yen Yen Tan38, R Manuel Teixeira112,113, Soo H Teo114,115, Mary Beth Terry116, Mads Thomassen117, Marc Tischkowitz118,119, Amanda E Toland120, Katherine M Tucker121,122, Nadine Tung123, Christi J van Asperen124, Klaartje van Engelen13, Elizabeth J van Rensburg53, Shan Wang-Gohrke125, Barbara Wappenschmidt62, Jeffrey N Weitzel126, Drakoulis Yannoukakos127, Mark H Greene80, Matti A Rookus85, Douglas F Easton5,128, Georgia Chenevix-Trench129, Antonis C Antoniou5, David E Goldgar130, Olufunmilayo I Olopade1, Timothy R Rebbeck131,132, Dezheng Huo1,133. 1. Department of Medicine, The University of Chicago, Chicago, IL. 2. Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL. 3. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China. 4. Division of Gastroenterology, Department of Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA. 5. Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. 6. Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. 7. Departments of Pediatrics and Medicine, Columbia University, New York, NY. 8. Division of Evolution and Genomic Sciences, Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, UK. 9. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 10. LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 11. Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. 12. Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands. 13. Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands. 14. Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL. 15. The University of Chicago Pritzker School of Medicine, Chicago, IL. 16. Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands. 17. Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. 18. Department of Pathology, National Institute of Oncology, Budapest, Hungary. 19. School of Medicine, University of Iceland, Reykjavik, Iceland. 20. Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 21. Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. 22. Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. 23. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada. 24. Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX. 25. Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands. 26. Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy. 27. Oncogénétique, Institut Bergonié, Bordeaux, France. 28. Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS. 29. Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. 30. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain. 31. Service de Génétique, Institut Curie, Paris, France. 32. Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA. 33. Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden. 34. Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA. 35. Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK. 36. Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. 37. Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain. 38. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. 39. Department of Medicine, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT. 40. Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain. 41. Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy. 42. Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. 43. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia. 44. Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada. 45. Centre for Medical Genetics, Ghent University, Ghent, Belgium. 46. Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands. 47. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN. 48. Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France. 49. Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA. 50. Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK. 51. N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 52. Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain (OD); Clinical Genetics Department, St Michael's Hospital, Bristol, UK. 53. Department of Genetics, University of Pretoria, Arcadia, South Africa. 54. City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA. 55. Ocogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK. 56. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. 57. Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology, Bellvitge Biomedical Research Institute), CIBERONC, Barcelona, Spain. 58. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. 59. The Ohio State University, Columbus Cancer Council, Columbus, OH. 60. The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. 61. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel. 62. Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. 63. Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC (CI). 64. Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK. 65. Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea. 66. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA. 67. Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. 68. Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea. 69. Department of Surgery, Soonchunhyang University Hospital Bucheon, Bucheon, Korea. 70. Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong. 71. Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. 72. Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong. 73. Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France. 74. Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea. 75. Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea. 76. Genetic Epidemiology of Cancer team, Institut Curie, Paris, France. 77. U900, INSERM, Paris, France. 78. PSL University, Paris, France. 79. Mines ParisTech, Fontainebleau, France. 80. Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD. 81. Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands. 82. Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany. 83. NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY. 84. Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 85. Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 86. Centre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK. 87. Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA. 88. Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 89. Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. 90. Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 91. Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA. 92. Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY. 93. Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY. 94. Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 95. West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK. 96. Department of Molecular Medicine, University La Sapienza, Rome, Italy. 97. Departments of Preventive Medicine and Biomedical Sciences, and Cancer Research Institute, Seoul National University, Seoul, Korea. 98. IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy. 99. Department of Urology, Medical University of Vienna, Vienna, Austria. 100. Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL. 101. Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy. 102. School of Women's and Children's Health, University of New South Wales Sydney, New South Wales, Australia. 103. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia. 104. Clinical Genetics, Karolinska Institutet, Stockholm, Sweden. 105. Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL. 106. Laboratoire de génétique médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France. 107. Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 108. Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, QC, Canada. 109. Department of Tumour Biology, Institut Curie, INSERM U830, Paris, France. 110. Université Paris Descartes, Paris, France. 111. Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany. 112. Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 113. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal. 114. Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. 115. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia. 116. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY. 117. Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark. 118. Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. 119. Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, UK. 120. Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH. 121. School of Medicine, University of New South Wales, Sydney, New South Wales, Australia. 122. Hereditary Cancer Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia. 123. Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA. 124. Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands. 125. Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany. 126. Clinical Cancer Genetics, City of Hope, Duarte, CA. 127. Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece. 128. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK. 129. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 130. Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT. 131. Harvard T.H. Chan School of Public Health, Boston, MA. 132. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. 133. Department of Public Health Sciences, The University of Chicago, Chicago, IL (DH).
Abstract
BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
Authors: P A van den Brandt; D Spiegelman; S S Yaun; H O Adami; L Beeson; A R Folsom; G Fraser; R A Goldbohm; S Graham; L Kushi; J R Marshall; A B Miller; T Rohan; S A Smith-Warner; F E Speizer; W C Willett; A Wolk; D J Hunter Journal: Am J Epidemiol Date: 2000-09-15 Impact factor: 4.897
Authors: Antonis C Antoniou; David E Goldgar; Nadine Andrieu; Jenny Chang-Claude; Richard Brohet; Matti A Rookus; Douglas F Easton Journal: Genet Epidemiol Date: 2005-07 Impact factor: 2.135
Authors: A Antoniou; P D P Pharoah; S Narod; H A Risch; J E Eyfjord; J L Hopper; N Loman; H Olsson; O Johannsson; A Borg; B Pasini; P Radice; S Manoukian; D M Eccles; N Tang; E Olah; H Anton-Culver; E Warner; J Lubinski; J Gronwald; B Gorski; H Tulinius; S Thorlacius; H Eerola; H Nevanlinna; K Syrjäkoski; O-P Kallioniemi; D Thompson; C Evans; J Peto; F Lalloo; D G Evans; D F Easton Journal: Am J Hum Genet Date: 2003-04-03 Impact factor: 11.025
Authors: Joanne Kotsopoulos; Olufunmilayo I Olopado; Parviz Ghadirian; Jan Lubinski; Henry T Lynch; Claudine Isaacs; Barbara Weber; Charmaine Kim-Sing; Peter Ainsworth; William D Foulkes; Andrea Eisen; Ping Sun; Steven A Narod Journal: Breast Cancer Res Date: 2005-08-19 Impact factor: 6.466
Authors: Su Yon Jung; Herbert Yu; Matteo Pellegrini; Jeanette C Papp; Eric M Sobel; Zuo-Feng Zhang Journal: Am J Cancer Res Date: 2021-04-15 Impact factor: 6.166
Authors: Frank Qian; Matti A Rookus; Goska Leslie; Harvey A Risch; Mark H Greene; Cora M Aalfs; Muriel A Adank; Julian Adlard; Bjarni A Agnarsson; Munaza Ahmed; Kristiina Aittomäki; Irene L Andrulis; Norbert Arnold; Banu K Arun; Margreet G E M Ausems; Jacopo Azzollini; Daniel Barrowdale; Julian Barwell; Javier Benitez; Katarzyna Białkowska; Valérie Bonadona; Julika Borde; Ake Borg; Angela R Bradbury; Joan Brunet; Saundra S Buys; Trinidad Caldés; Maria A Caligo; Ian Campbell; Jonathan Carter; Jocelyne Chiquette; Wendy K Chung; Kathleen B M Claes; J Margriet Collée; Marie-Agnès Collonge-Rame; Fergus J Couch; Mary B Daly; Capucine Delnatte; Orland Diez; Susan M Domchek; Cecilia M Dorfling; Jacqueline Eason; Douglas F Easton; Ros Eeles; Christoph Engel; D Gareth Evans; Laurence Faivre; Lidia Feliubadaló; Lenka Foretova; Eitan Friedman; Debra Frost; Patricia A Ganz; Judy Garber; Vanesa Garcia-Barberan; Andrea Gehrig; Gord Glendon; Andrew K Godwin; Encarna B Gómez Garcia; Ute Hamann; Jan Hauke; John L Hopper; Peter J Hulick; Evgeny N Imyanitov; Claudine Isaacs; Louise Izatt; Anna Jakubowska; Ramunas Janavicius; Esther M John; Beth Y Karlan; Carolien M Kets; Yael Laitman; Conxi Lázaro; Dominique Leroux; Jenny Lester; Fabienne Lesueur; Jennifer T Loud; Jan Lubiński; Alicja Łukomska; Lesley McGuffog; Noura Mebirouk; Hanne E J Meijers-Heijboer; Alfons Meindl; Austin Miller; Marco Montagna; Thea M Mooij; Emmanuelle Mouret-Fourme; Katherine L Nathanson; Bita Nehoray; Susan L Neuhausen; Heli Nevanlinna; Finn C Nielsen; Kenneth Offit; Edith Olah; Kai-Ren Ong; Jan C Oosterwijk; Laura Ottini; Michael T Parsons; Paolo Peterlongo; Georg Pfeiler; Nisha Pradhan; Paolo Radice; Susan J Ramus; Johanna Rantala; Gad Rennert; Mark Robson; Gustavo C Rodriguez; Ritu Salani; Maren T Scheuner; Rita K Schmutzler; Payal D Shah; Lucy E Side; Jacques Simard; Christian F Singer; Doris Steinemann; Dominique Stoppa-Lyonnet; Yen Yen Tan; Manuel R Teixeira; Mary Beth Terry; Mads Thomassen; Marc Tischkowitz; Silvia Tognazzo; Amanda E Toland; Nadine Tung; Christi J van Asperen; Klaartje van Engelen; Elizabeth J van Rensburg; Laurence Venat-Bouvet; Jeroen Vierstraete; Gabriel Wagner; Lisa Walker; Jeffrey N Weitzel; Drakoulis Yannoukakos; Antonis C Antoniou; David E Goldgar; Olufunmilayo I Olopade; Georgia Chenevix-Trench; Timothy R Rebbeck; Dezheng Huo Journal: Br J Cancer Date: 2019-06-19 Impact factor: 9.075
Authors: Adriana M Coletta; Susan K Peterson; Leticia A Gatus; Kate J Krause; Susan M Schembre; Susan C Gilchrist; Banu Arun; Y Nancy You; Miguel A Rodriguez-Bigas; Larkin L Strong; Karen H Lu; Karen Basen-Engquist Journal: Hered Cancer Clin Pract Date: 2020-03-07 Impact factor: 2.857
Authors: Su Yon Jung; Jeanette C Papp; Eric M Sobel; Matteo Pellegrini; Herbert Yu; Zuo-Feng Zhang Journal: Front Oncol Date: 2021-02-03 Impact factor: 6.244
Authors: Mathew Vithayathil; Paul Carter; Siddhartha Kar; Amy M Mason; Stephen Burgess; Susanna C Larsson Journal: PLoS Med Date: 2021-07-29 Impact factor: 11.613