Ron Neumann1, Dana Barequet2, Amir Rosenblatt2, Radgonde Amer3, Yael Ben-Arie-Weintrob4, Tamar Hareuveni-Blum5, Vicktoria Vishnevskia-Dai6, Eyal Raskin7, Oren Blumenfeld8, Shiri Shulman2, Juan M Sanchez3, Victor Flores4, Zohar Habot-Wilner2. 1. a Private Inflammatory Eye Disease Clinic , Tel-Aviv , Israel. 2. b Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Tel Aviv , Israel. 3. c Department of Ophthalmology , Hadassah Medical Center, The Hebrew University Hadassah Medical School , Jerusalem , Israel. 4. d Department of Ophthalmology, Rambam Medical Center, The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Israel Institute of Technology , Haifa , Israel. 5. e Department of Ophthalmology, Faculty of Medicine in the Galilee , Galilee Medical Center, Bar Ilan University , Naharia , Israel. 6. f The Goldschleger Eye Institute, Department of Ophthalmology, Sheba Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Ramat Gan , Israel. 7. g Department of Ophthalmology , Barzilai University Medical Center, Ben-Gurion University , Ashkelon , Israel. 8. h Department of Ophthalmology, Wolfson Medical Center, Sackler Faculty of Medicine , Tel Aviv University , Holon , Israel.
Abstract
PURPOSE: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. METHODS: Multicenter, retrospective study of AU patients diagnosed clinically and by polymerase chain reaction (PCR). RESULTS: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05). CONCLUSION: Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease.
PURPOSE: To describe the demographics and clinical characteristics of patients with herpetic anterior uveitis (HAU), and compare characteristics by pathogen, recurrence, and association to iris atrophy. METHODS: Multicenter, retrospective study of AUpatients diagnosed clinically and by polymerase chain reaction (PCR). RESULTS: The study included 112 eyes in 109 patients: 54 (48.2%) HSV, 34 (30.4%) VZV, 2 (1.8%) CMV, and 22 (19.6%) unspecified diagnosis. HSV eyes, compared to VZV, had a higher recurrence rate, corneal involvement, KPs, iris atrophy, elevated IOP and posterior synechia (p < 0.05). VZV patients had more frequent immunomodulatory treatments and history of systemic herpetic disease (p < 0.05). Fifty-nine (52.7%) eyes had recurrent disease. Iris atrophy was associated with a higher prevalence of posterior synechia, dilated distorted pupil, and high IOP (p < 0.05). CONCLUSION: Different HAU-causing Herpesviridae produce common clinical findings; therefore, PCR should be used more often to confirm specific diagnosis. Iris atrophy was associated with more severe disease.