| Literature DB >> 30310670 |
Neha Bhardwaj1,2, Satish K Pandey1, Jyotsana Mehta1,2, Sanjeev K Bhardwaj1,2, Ki-Hyun Kim3, Akash Deep1,2.
Abstract
More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal-organic frameworks (nMOFs) - IRMOF-3, MOF-5, and Zn-BTC - were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli, Staphylococcus aureus, Staphylococcus lentus, and Listeria monocytogenes, the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.Entities:
Year: 2018 PMID: 30310670 PMCID: PMC6116815 DOI: 10.1039/c8tx00087e
Source DB: PubMed Journal: Toxicol Res (Camb) ISSN: 2045-452X Impact factor: 3.524